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Critical role of conserved histidine pairs HNXXH and HDXXH in recombinant human phosphodiesterase 4A. Cell. Signal - Omburo, Jacobitz, et al. - 1998 () Citation Context ...rophilic areas of the molecule and may be involved in its biological function. Histidine motifs have been shown to ...
The sequence alignment of these domains has revealed the presence of two histidine motifs: motif I, HNXXH, and motif II, HDXXH. These amino acid sequences are canonical motifs, which act as ligands for divalent metal cations required for catalytic activity. In this paper, we report human ...
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