早年衰老综合症(Hutchinson-Gilford Progeria syndrome),简称早衰症。1886年Hutchinson首例报道,1897年Guilford进一步描述,所以也称Hutchinson-Gilford综合征.后来文献中称为HGPS.流行病学调查显示,美国本病的发病率为1/800万,男女之比为1.5:1,97%为白色人种.早衰症是一种极端罕见的先天遗传性疾病,其患者身体的老化过程...
Synonyms Laminopathies; Progeria Definition Hutchinson-Gilford progeria syndrome (HGPS), often referred to as progeria, is an extremely rare autosomal dominant neonatal condition. Children with HGPS have a small stature, distinctive facial features and rapid aging in many organ systems. Progeria is a...
Progeria, also known as Hutchinson-Gilford progeria syndrome (HGPS), is a rare genetic condition that results in a child's body aging rapidly. A mutation in the LMNA gene causes it to make an abnormal protein. When cells use this protein, called progerin, they break down more easily, whic...
Hayley suffers from Hutchinson Gilford Progeria syndrome - which makes her body age 10 times faster than normal. Running for Harry and Hayley The most severe disorders linked to mutation in this gene include Hutchinson Gilford Progeria Syndrome (HGPS), a fatal disease that causes premature ageing ...
Hutchinson-Gilford-Progeria综合征(HGPS)是一种节段性早衰性疾病,可导致患者因心血管功能不全而在青少年早期死亡。虽然HGPS不能完全再现正常的衰老过程,但它确实与正常的衰老过程有许多相似之处,患者还发展为心血管疾病、脱发、骨关节异常和脂肪变化。因此,毫不奇怪的是,随着医生和科学家寻找治疗HGPS的方法,他们已经...
Hutchinson–Gilford progeria syndromeInduced pluripotent stem cellsMechanotransductionSenescenceStem cellsVascular agingHutchinson-Gilford progeria syndrome (HGPS) is a premature aging disorder caused by a de novo genetic mutation that leads to the accumulation of a splicing isoform of lamin A termed pro...
Hutchinson-Gilford progeria syndrome (HGPS) is a rare pediatric genetic syndrome with incidence of one per eight million live births. The disorder is characterised by premature aging, generally leading to death at approximately 13.4 years of age. This is a follow-up study of a 9-year-old male...
Hutchinson-Gilford progeria syndrome (HGPS) is a rare but well known entity characterized by extreme short stature, low body weight, early loss of hair, lipodystrophy, scleroderma, decreased joint mobility, osteolysis, and facial features that resemble aged persons. Cardiovascular compromise leads to ...
Hutchinson-Gilford Progeria Syndrome: Challenges at Bench and BedsideCalcitriolHGPSHutchinson Gilford progeria syndromeLaminsPremature ageingProgerinRetinoidsThe structural nuclear proteins known as "lamins" (A-type and B-type) provide a scaffold for the compartmentalization of genome function that is ...
Hutchinson-Gilford progeria syndromeIndirect bypassPediatricStrokeHutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder characterized by premature aging. Cerebral hypoperfusion and stroke have been described in HGPS however revascularization techniques have not been reported from a neurosurgical ...