: Xenotransplantation of porcine fetal ventral mesencephalon in a rat model of Parkinson’s disease: functional recovery and graft morphology. Exp Neurol 1996, 140: 1–13. Article PubMed CAS Google Scholar Anderson KD, Panayotatos N, Corcoran TL, et al.: Ciliary neurotrophic factor protects ...
In a variety of neuronal injury models, neurotrophic factors have been shown to protect neurons from death and to promote functional recovery. Thus, neurotrophic factors have long been suggested as therapeutic candidates for neurodegenerative disorders in- cluding Parkinson disease and HD. Beneficial ...
36). To assess whether the polyQ67-YFP foci were immobile protein aggregates, we performed a quantitative fluorescence recovery after photobleaching analysis of head neurons. In both empty vector and ubr-5 RNAi-treated worms, most of the polyQ67-YFP foci signal could not be recovered, ...
Full motor recovery despite striatal neuron loss and formation of irreversible amyloid-like inclusions in a conditional mouse model of Huntington’s disease J. Neurosci., 25 (2005), pp. 9773-9781 View in ScopusGoogle Scholar 13 S.Q. Harper, P.D. Staber, X. He, S.L. Eliason, I.H. ...
(ii) The sole effect of bodyweight recovery after a treatment start at 29 weeks of age could be used as early post-onset evaluation, representing best the sporadic patients' situation. Here, the analysis horizon should be at least 14 weeks (43 weeks of age). (iii) To screen for new ...
Limited number of successful clinical trials found effective recovery and integration of medium spiny neurons (MSNs) after transplantation of developing MSNs taken from the fetal brain [110]. The other approaches, which focused on reducing cellular toxicity of mHtt by targeting different biologically ...
This suggests that antioxidant function was not sufficient for neural function recovery. Moreover, these results suggested that the beneficial effect of 4QMn was exclusively due to the induction of other pathways or cellular processes. In this regard, it has been described before that reduction in ...