Proud Partner of Huntington Health “Joining Huntington Health, an affiliate of Cedars-Sinai, will provide access to extraordinary resources and support that will directly benefit our patients for years to come,” Bryan Jick, MD, medical director of Fair Oaks Women’s Health. ...
Adam Labadorf, Andrew G. Hoss & Richard H. Myers 2783 Accesses Abstract Multiple lines of evidence have implicated neuroinflammation as both a cause and an effect of neurodegeneration in Huntington’s disease (HD). Studies of post mortem human HD brains and HD mouse models have demonstrated ...
The study found evidence that the molecule compound called Naphthyridine-Azaquinolone (NA) can recognize slipped-DNAs and reverse the mutation—essentially causing a contraction of the expansion. In the lab, the research team was able to successfully reduce the repeat expansions in the brain of a ...
National eHealth Living Lab, Leiden University Medical Center, Leiden, The Netherlands Pearl J. C. van Lonkhuizen, Niels H. Chavannes & Eline Meijer Huntington Center Topaz Overduin, Katwijk, The Netherlands Pearl J. C. van Lonkhuizen, Anne-Wil Heemskerk & Erik van Duijn Department of Neurolo...
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The mechanisms underlying the selective regional vulnerability to neurodegeneration in Huntington’s disease (HD) have not been fully defined. To explore the role of astrocytes in this phenomenon, we used single-nucleus and bulk RNAseq, lipidomics, HTT g
Molecular Genetic Lab Special Medical Center Tehran IranParvin ShariatiMaryam RostamiMasoumeh Dehghan ManshadiTayebeh MajidizadehCellular & Molecular NeurobiologyHuntington’s Disease and Mitochondrial DNA Deletions: Event or Regular Mechanism for Mutant Huntingtin Protein and CAG Repeats Expansion?![J] . ...
“developmental process” in the cell types with the most DEGs, such as in OLs and OPCs. Similar to the GO analysis data there were recurring KEGG pathways across regions, ages, and cell types as well as sets of unique pathways that group together (Supplementary Fig.2b). We also ...
American College of Medical Genetics: Bethesda, MD 2002. The Huntington’s Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes. Cell 1993;72:971–983. Article Google Scholar Riess O, Noerremoelle ...
All subjects were examined by an experienced neurologist using the motor section of the Unified Huntington's Disease Rating Scale (UHDRS) as described previously.12 All the controls were free of known medical conditions. Age considered for the analysis was the age at the time of blood collection...