IntroductionHuntington disease is a progressive neurodegenerative disorder without a cure. Its clinical presentation makes complex the care of patients with HD, further impacted by the progressive loss of dependence and disability. Intuitively, HD management calls for multispecialty care.Methodsliterature ...
To formally measure possible epigenetic AgeAccel effects due to HD disease status, we fit a regression model of DNAm age on chronological age and defined AgeAccel as the resulting raw residual. Thus, positive AgeAccel means the methylation state of the sample appears to be older than would be...
Cases of adult-onset HD with prominent dystonia and a paucity of chorea may represent 1 in 8 cases in specialty clinics. Age of onset was clearly associated with the motor phenotype. A younger age of o...