Myles, DeanBerthelier, Valerie
“This research marks the first time that we have been able to identify a specific chemical change that is unique to the development of Huntington’s disease, which opens the possibility of developing new tests to study the early changes of the disease before irreversible damage occurs. “Underst...
Scientists around the world are working to findeffective therapiesfor Huntington's disease. While the disease is caused by a single gene mutation, the manifestation of the disease at a molecular level is nevertheless highly complex and involves multiplecellular processes. In research, this complexity ...
There is currently no cure and whilst some symptoms can be alleviated, no treatments have been developed that help with cognitive deficits, a distressing aspect of the disease. Whilst useful mouse models mimicking this disorder have been developed, it has been difficult to test cognitive skills suc...
Huntington's disease is an inherited neurological disease that affects about 30, 000 Americans and for which there is no effective treatment or cure. An important step to developing new treatments was announced last week when scientists at the Yerkes National Primate Research Center in Atlanta publis...
Experimental therapies for HD currently are being tested in animal models and human trials. Awareness of ongoing research to find an effective cure for HD must be a part of the care plan of an individual patient and the patient's family. ...
The initial observation of an expanded and unstable trinucleotide repeat in the Huntington's disease gene has now been confirmed and extended in 150 indepe... M Duyao,C Ambrose,R Myers,... - 《Nature Genetics》 被引量: 2320发表: 1993年 The Huntington's Disease Collaborative Research Group....
Today, approximately 150 years later, the HD literature is filled with thousands of peer-reviewed, original research articles from the efforts of scientists around the globe who have made extraordinary progress in advancing our understanding of this disease. During this time, the genetic mutation that...
collaborative efforts that led to the identification of theHTTgene and its mutations will continue into the future as we search for a cure for HD. Indeed, research teams throughout the world are currently exploring a wide range of molecular therapeutic approaches to combat this deadly disease. ...
(The Huntington's Disease Collaborative Research Group, 1993). This protein has a molecular mass of 330 kDa but its function remains unknown. Pathological mutations of thehuntingtingene, involving expansion of CAG repeats, result in stretches of polyglutamines of greater than 39 contiguous glutamine ...