anti-IgEHRP , Horseradish peroxidaseIV , IntravenousPBS , Phosphate-buffered salinerhuMAb-E25 , Recombinant human monoclonal antibody E25SC , SubcutaneousBackground: Increased serum levels of antigen-specific IgE are often associated with allergic respiratory disorders. RhuMAb-E25, a recombinant humanized...
The results of this study suggest that -IgG and MaE11 may have important immunotherapeutic benefit for the amelioration of IgE-mediated diseases. 展开 关键词: IGE HUMAN LUNG SENSITIZATION ANTIBODY DOI: 10.1016/0091-6749(94)90151-1 被引量: 275 ...
Omalizumab, a recombinant, humanised monoclonal antibody against IgE, will be introduced soon for the treatment of . This antibody binds circulating IgE mo... M Soler - 《International Journal of Clinical Practice》 被引量: 15发表: 2001年 Anti-IgE therapy with omalizumab for severe asthma: curre...
This manuscript emphasizes on new generation monoclonal human (ized) antibodies in asthmatics and off-label use . The first developed biologic agent is the anti-immunoglobulin E monoclonal antibody called omalizumab. Currently it is an approved treatment option for asthma.The other human(ized) ...
The role of IgE in allergen-induced inflammation and the potential for intervention with a humanized monoclonal anti-IgE antibody. Clin Exp Allergy 2001; 31: 1344–51.Arshad SH, Holgate S, The role of IgE in allergen-induced inflammation and the potential for intervention with a humanized ...
Characterization of com- plex formation by humanized anti-IgE monoclonal antibody and monoclonal human IgE. Biochemistry 1995; 34:10474- 10482. 32 Muller YA, Chen Y, Christinger HW, et al. VEGF and the Fab fragment of a humanized neutralizing antibody: crystal struc- ture of the complex at...
There is a related need in the art for humanized or other chimeric human/mouse monoclonal antibodies. In well publicized studies, patients administered murine anti-TNF (tumor necrosis factor) monoclonal antibodies developed anti-murine antibody responses to the administered antibody. (See, e.g., Exl...
Treatment of Childhood Asthma With Anti-Immunoglobulin E Antibody (Omalizumab) Omalizumab (rhuMAb-E25) is a recombinant, humanized, monoclonal anti-IgE antibody of mouse origin developed for the treatment of IgE-mediated diseases. ... H Milgrom,W Berger,A Nayak,... - 《Pediatrics》 被引量: ...
We developed a novel humanized anti-CD132 monoclonal antibody, named as 2D4. 2D4 efficiently blocked IL-21 and IL-15, with limited effectiveness against IL-2, thereby suppressing T and B cells without disrupting immune tolerance. In the mouse immunization model, 2D4 virtually inhibited T cell...
the chimeric human antibodies of the invention will not cause anti-mouse immunoglobulin antibody production in the patient's body but shows a prolonged blood half-life, with a reduced frequency of adverse effects, so that it can be expected to be superior to mouse monoclonal antibodies in the ...