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Although 90% of children with acute lymphoblastic leukemia (ALL) are now cured, the prognosis for infant-ALL remains dismal. Infant-ALL is usually caused by a single genetic hit that arisesin utero:anMLL/KMT2Agene rearrangement (MLL-r). This is sufficient to induce a uniquely aggressive and ...
First, we assessed whether C9 COs at 220 DIV are more prone to UPR activation by an ALS/FTD-relevant oxidative stressor, sodium arsenite (SA), and whether overactivation can be prevented by short- or long-term treatments with GSK2606414 (GSK onwards), which is a repressor of translational ...
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RNA-seq libraries were prepared from total RNA with two types of RNA enrichment methods: (1) poly(A) enrichment libraries, applied to RNA from peripheral blood and nasal epithelium (n = 38); and (2) ribo-depletion libraries, applied to RNA from large airway epithelium (n = 49)...
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1). While the PARs and the short arm are euchromatic, a large portion of the long arm is heterochromatic with the exception of the proximal portion juxtaposed to the centromere which is euchromatic in nature. Fig. 1 Structure of the human Y chromosome. The Pseudo Autosomal Regions [PAR1 ...
5a). We also established that the overall distribution of surface interactions has affinities centred in the low micromolar range, although with a long tail of higher-affinity interactions (Extended Data Fig. 5b). In a test of previous theoretical predictions23,24 we found that higher expression...
Behavioral assays were performed according to established protocols referenced here: nest building with shredded paper [46], self-grooming [47], light–dark box [48], tail suspension test [49], and three-chamber social interaction test [50]. Both males and females were used for all behavioral...
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