We report novel high- and low- abundance proteomes of young, adult, and aged human hearts, with relative abundances to total proteins and each other. We found that adult ECM had extracellular galactin-1, fibronectin, fibrillins, and perlecan (HSPG2) which are implicated in normal heart ...
Heart weight, ventricular wall thicknesses, and valve circumferences were measured in 200 autopsy specimens of normal hearts from persons who ranged from birth to 19 years old. During this period of body growth, all cardiac measurements increased progressively and correlated with both age and body ...
We have examined at cellular and molecular level the proliferation, apoptosis and commitment of CPCs isolated from normal (CPC-N) and age-matched pathological adult human hearts (CPC-P) with ischemic heart disease. In the CPC-P, genes related to early stages of developmental processes, nervous ...
whereas both adult and fetal hearts received similar signals from fetal epicardium (Fig.4e). Specifically, signaling from fetal epicardium consisted ofNRP2-mediated signaling with endothelialVEGFs. However, it is unknown whether epicardialNRP2is soluble or membrane-anchored as part of this established...
Genome-wide expression profiling was performed using the Affymetrix platform and the data were analyzed with R and Bioconductor considering adjusted < 0.05 significant. In AS, fibrosis-related genes were induced in male samples, while ribosomal and energy-related genes were repressed. Female-specific ...
For example, on the one hand, the morphology of the ML lined with endocardial-like cells in HFOs is reminiscent of a pre-heart-tube-like stage at ~2–3 weeks of human gestation14 resembling a single heart-forming region. On the other hand, in the human embryo, liver bud development ...
functional analysis of myocardial performance in murine hearts overexpressing the human 2 -adrenergic receptor Transgenic mice overexpressing the human beta 2-adrenergic receptor gene were compared with wild mice type in terms of cardiac function, using a modified w... HB Bittner,EP Chen,CA Milano,...
A look at the the objective, biological differences between male and female bodies reveals that men have larger brains, hearts, and feet, but have an inferior sense of smell, sight, and taste. Women have a harder time dealing with the cold and cry more, but men a...
Isolated rat hearts subjected to I/R were treated at the onset of reperfusion with: 1) GHRH; 2) GHRH+GHRH antagonist JV-1-36; 3) GHRH+... Claudia,Penna,Fabio,... - 《Endocrinology》 被引量: 44发表: 2013年 A method for evaluation of activity of antagonistic analogs of growth hormone...
Figure 2 A whole-body map of sex differences in gene co-expression. (A) A cartoon of the human body is shown with the tissues that are used in our study. For each tissue, the number of genes that are either male- (blue) or female-biased (red) are shown in a piechart. The bigge...