Similar skewing toward enhanced accessibility of core inflammation genes was observed when membrane vs. bone marrow (89 up,P = 1.2 × 10−13), inflamed air pouch vs. blood (85 up,P = 1.5 × 10−11), and inflamed air pouch vs. bone marrow (100 up,P = 2....
we carried out differential gene expression analysis between allMLL-AF4infant-ALL (n = 19) andMLL-AF4childhood-ALL (n = 5) samples. We identified 617 significantly differentially expressed genes (false discovery rate (FDR) < 0.05), 193 of which were upregulated inMLL-AF4infant...
Fig. 3. Examples of cut-marks on several taxa from Level IV faunal assemblage: a: long bone metaphysis attributed to small-sized animal; b: distal epiphysis of Cervus elaphus first phalanx; c: flat bone of medium-sized animal; d: long bone diaphysis of small-sized animals; e: distal en...
AnimalTFDB 3.0: a comprehensive resource for annotation and prediction of animal transcription factors. Nucleic Acids Res. 47, D33–D38 (2019). CAS PubMed Google Scholar Efremova, M., Vento-Tormo, M., Teichmann, S. A. & Vento-Tormo, R. CellPhoneDB v2.0: Inferring cell-cell ...
The failure of animal models to predict therapeutic responses in humans is a major problem that also brings into question their use for basic research. Organ-on-a-chip (organ chip) microfluidic devices lined with living cells cultured under fluid flow can recapitulate organ-level physiology and pa...
. The high correlation of the transcriptomics data of the common cell lines suggested that the batch effects can hardly be observed between the two different datasets. This may be attributed to the fact that cell lines generally exhibit more stable characteristics than animal models where ...
limiting the use of this common laboratory animal for studying the contribution of telomere biology to aging and cancer. We identified a key amino acid variation in the helicase RTEL1, naturally occurring in the short-telomere mouse speciesM. spretus. Introducing this variation intoM. musculusis ...
These studies, and others performed in animal models21, have established similarities between the neural substrates of visual perception and visual memory. However, relatively less attention has been paid to identifying and explaining differences between activity patterns evoked during perception and memory...
Cranial vault shape, herein defined as the outer head surface encompassing the supraorbital ridge and extending towards the occipital bone, was extracted from structural MRIs (Supplementary Fig.1; Methods). Since the outer soft-tissue layer in this region is thin and uniform31, shape variation asso...
IGFBP3,IGFBP4,IGFBP6,IGFBP7andFASwas upregulated in aged TNF+MuSCs (Supplementary Fig.3). Moreover, FACS of MuSC subtypes showcased specific upregulation ofCDKN2AandCDKN1Agenes in aged TNF+compared to ICA+and Main MuSCs (Fig.2kand Extended Data Fig.3i). In animal models, ribosome assembly ...