Similar skewing toward enhanced accessibility of core inflammation genes was observed when membrane vs. bone marrow (89 up,P = 1.2 × 10−13), inflamed air pouch vs. blood (85 up,P = 1.5 × 10−11), and inflamed air pouch vs. bone marrow (100 up,P = 2....
Kleiber–West law46,47. On the one hand, the energy requirements for the organism maintenance increase linearly as the body mass grows and hence the initial excess metabolic power drives the growth of the organism until it reaches the dynamic equilibrium corresponding to the mature animal state. ...
Most microbial metabolic pathways (85%) associating with one or more metabolites in faeces also associated with one or more metabolites in blood (Supplementary Table5). In contrast, the majority of microbial species only associated with faecal metabolites alone (58%, Supplementary Table5). Still, ...
Ernst Mayr (2002) argued that “before the voyages of European discovery and subsequent rise of a global economy” human subspecies were basically identical to races in the animal world (Mayr, 2002, p. 131). However, in the last decades, this position, dominant especially in human population...
thereby highlighting important improvements in standardizing methods for human disease modeling. Although previous animal and stem-cell-based models have implicated many cell types in ALS and FTD pathogenesis13, human cell models have been limited in resolving the temporal relationship of early cell-type...
Despite the overt need for improved treatment modalities in depression, efforts to develop conceptually novel antidepressants have been relatively unsuccessful so far. Here we present a translational approach combining results from hypothesis-free animal
animalis (Fa, also known as Fn subspecies animalis) had higher abundance and prevalence than Fn in tumor samples29. In line with this finding, we found Fa in more samples with higher coverage than Fn in our cohort (Fig. 3). Fa prevalence, popANI, and nucleotide diversity values showed ...
we investigated the cytokine expression of RSF from human donors and its effect on human glomerular EC and PO. We strictly remained in the human system, although there are disadvantages when compared to animal studies, e.g. the number of donors is limited, the donors are less well characterize...
the limited number and proliferation ability of isolated primary trophoblasts restricts their widespread use. Although animal models are commonly employed to study placental development and have been instrumental in advancing our collective understanding of placentation, there are key anatomical and physiologi...
Epstein-Barr virus, post-transplant lymphoproliferative disease and animal models. Rev Med Microbiol. 2002;13:129–40. Article Google Scholar Johannessen I, Asghar M, Crawford DH. Essential role for T cells in human B-cell lymphoproliferative disease development in severe combined immunodeficient ...