However, novel approaches based on comprehensive data analyses and revitalisation of an ancient plasma milieu in vitro assay connected inflammation with immunosuppressive factors in tuberculosis. Moreover, interrelations between the aberrant plasma milieu and immune cell pathology were observed. This review ...
Tuberculosis (TB) is still a major worldwide health threat and primarily a lung disease. The innate immune response against Mycobacterium tuberculosis (Mtb) is orchestrated by dendritic cells, macrophages, neutrophils, natural killer cells and apparently mast cells (MCs). MCs are located at mucosal...
A key aspect of TB pathogenesis that maintains Mycobacterium tuberculosis in the human population is the ability to cause necrosis in pulmonary lesions. As
Tuberculosis Tuberculosis was the primary cause of death among Westerners of all ages during the eighteenth and nineteenth centuries when industrialization and urbanization surged, and continues to be a primary contributor to mortality in some parts of the world in modern times. In fact, approximately...
Besides the role of CR1 in facilitating the entry of intracellular pathogens into host cells, CR1 protein levels were shown to be associated with the pathogenesis of different diseases including malaria28, tuberculosis36, lepromatous leprosy37, severe acute respiratory syndrome33, chronic liver diseases...
Viruses are obligate intracellular pathogens that cause infection in susceptible host cells. Virus infections could be lytic, chronic, latent or immortalizing. Viruses causing latent infection are associated with high morbidity and mortality worldwide. The human body is protected from viral infection by...
Paragonimiasis is a foodborne trematode infection of the lungs caused by Paragonimus spp., presenting clinically with similar symptoms to active tuberculosis (TB). Worldwide, an estimated 20.7 million people are infected with paragonimiasis, but relatively little epidemiological data exists for Africa. ...
1) A study of the bronchi of 60 lungs or lobes which were surgically resected for pulmonary tuberculosis showed tuberculosis of the larger bronchi in 31 of the cases.2) Endobronchial tuberculosis is a condition secondary to parenchymal t... WA Meissner - 《Diseases of the Chest》 被引量: 24...
The progression of tuberculosis from a latent, subclinical infection to active disease that culminates in the transmission of infectious bacilli is determined locally at the level of the granuloma. This progression takes place even in the face of a robust immune response that, although it contains ...
, 1816–1825 (2012). PubMedPubMed CentralGoogle Scholar Mycobacterium tuberculosis evades macrophage defenses by inhibiting plasma membrane repair., 899–906 (2009). The role of prostaglandin E2 in the immunopathogenesis of experimental pulmonary tuberculosis....