By analyzing genomic data we can detect and use the footprints that adaptive (positive) natural selection leaves in our genome to identify human adaptations at different timescales, as well as the resulting phenotypical traits that in current populations define us as humans. Although genomics has ...
PIGEON: a statistical framework for estimating gene–environment interaction for polygenic traits PIGEON is a statistical framework that uses summary statistics from genome-wide interaction studies to estimate how genes and environments jointly influence human complex traits. Jiacheng Miao Gefei Song Qiong...
Given the large benefits produced by altruistic cooperation, it safe to assume that throughout human evolutionary history groups of altruistic cooperators would have thrived at the expense of groups of non-altruists. However, any explanation that invokes the (natural) selection of traits that ...
are limited by our use of exclusively European data and the use of genome-wide association study data, which identify associations between genetic variants and phenotypes that may not be causal. In sum, we provide an overview of signals of selection on human polygenic traits and their ...
(1918)groundbreaking paper formed the basis for this development, specifically the recognition that phenotypic traits are polygenic, and that their inheritance does not follow a simple Mendelian model. While this advancement in the field of genetics provided a more sophisticated, more quantitative ...
The process of gait feature extraction (visual traits) is followed by segmenting and identification of human body parts based on thekinematic jointpoints. The stick figure (skeletonization) is constructed by connecting the segmented body parts and fuses the visual and skeletal traits. Afterward, spat...
Moreover, (intercept − 1)/(mean(χ2) − 1) was less than 0.12, further supporting the conclusion that HASV traits were influenced more by polygenicity than population structure (Additional file 1: Table S3). Observed scale heritability (h2) was estimated using the slope of L...
D. Innate and adaptive immune traits are differentially affected by genetic and environmental factors. Nat. Commun. 8, 13850 (2017). Article CAS PubMed PubMed Central Google Scholar Li, Y. et al. A functional genomics approach to understand variation in cytokine production in humans. Cell ...
10f). This suggests that LTi-like ILC3 subsets are expanded during the development of gut-associated lymphoid tissues, but not during the development of mLN. Single-molecule fluorescence in situ hybridization (smFISH) staining identified all three LTi-like subtypes (Extended Data Fig. 10g) and ...
The conducted research shows that industrial companies in Poland have more of a short-sighted perspective when it comes to developing the potential of their engineers. The HR development practices focusing only on current needs are not in line with the SHRM principles of a long-term perspective an...