12c). LEC2 cells expressed TNFRSF9, THY1, CXCL5 and CCL20—as described in human lymph nodes31—as well as targets of the NF-κB pathway and adhesion molecules including MADCAM1, VCAM1 and SELE, suggesting their involvement in lymphocyte trafficking (Extended Data Fig. 12d, e). We ...
H. Multiple roles for membrane-associated protein trafficking and signaling in gravitropism. Front. Plant Sci. 3, 274 (2012). Article PubMed PubMed Central Google Scholar Wang, B., Smith, S. M. & Li, J. Y. Genetic regulation of shoot architecture. Annu. Rev. Plant Biol. 69, 437–...
Here, we describe two classes of novel, potent small molecules identified from screening compound libraries that restore the function of DeltaF508-CFTR in both recombinant cells and cultures of human bronchial epithelia isolated from CF patients. The first class partially corrects the...
Notably, and in line with observations of other ABC transporters, the butyrate analogue, 4-PBA, demonstrates the capacity to rescue PXE-associated ABCC6 trafficking mutations. Specifically, 4-PBA-mediated restoration of ABCC6 plasma membrane expresion has been observed in mutant ABCC6-expressing ...
, an increased probability of degradation, impaired trafficking, lost binding partners or oxidative damage. All these factors can act independently, additively or synergistically. Protein-conformation diseases can affect a single organ or be spread through multiple tissues. For example, numerous amyloid...
The NPC1 gene encodes a protein involved in intracellular lipid trafficking; its second endosomal loop (loop 2) is a receptor for filoviruses. A polymorphism (His215Arg) in NPC1 was associated with obesity in Europeans. Adaptations to diet and pathogens represented powerful selective forces; thus...
It’s Now or Never: Stop Dog Trafficking Now! National Animal Interest Alliance NAIA. 2019. Available online: https://www.naiaonline.org/articles/article/its-now-or-never-help-stop-dog-trafficking-now (accessed on 28 January 2020). Centers for Disease Control and Prevention (CDC). Federal ...
Receptor Type F Myosin IC Family with Sequence Similarity 127 Member B Thyroid Hormone Receptor Interactor 10 Serpin Family G Member 1 Target of Myb1 Like 2 Membrane Trafficking Protein The Human Protein Atlas [8] Expressed in all Mixed Expressed in all Mixed Mixed Expressed in all Expressed in...
The Group additionally requires them to support the prohibition of human trafficking, forced and child labor and discrimination, to support freedom of association and collective bargaining rights, and to promote policies such as pay equity. Supply Chain RiskInitiativeAchievements in FY2023 Supply chain ...
Responding to the UK Modern Slavery Act In accordance with the Modern Slavery Act that came into force in the UK in 2015, we have released the following statement on slavery and human trafficking. Link: Statement pertaining to the UK Modern Slavery ActRelated...