Tooth development is complex process and proceeds in three stages: bud, cap, and bell stages.Many genes have been discovered that regulate dental tissue proliferation and morphogenesis.A total of 21 hub genes were identified associated with the tooth development.Most of these genes are linked to ...
The researchers believe these findings could one day lead to the development of biological tooth substitutes that could be used in place of imperfect synthetic dental implants currently used. The paper’s findings were first spotted by MIT Technology Review. Dental researchers from Tufts University ...
During early tooth development, the transcription factors PAX9 and MSX1 act synergistically to induce tooth initiation. The prime odontogenic potential lies in the dental epithelium. With the expression of FGFs and BMPs by the epithelium and subsequent induction of PAX9 and MSX1 in the mesenchyme, ...
3a, b). Retinoic acid, being a key morphogen, is known to control dental development and self-renewal32,33. Correspondingly, complementary receptor genes Rara, Rarb, and Rarg are expressed in some of the major populations of the tooth itself (Supplementary Fig. 3a, b). This suggests ...
(Ogawa et al.2006; Lin et al.2008; Suzuki et al.2009; He et al.2010; Suazo et al.2010; Sahoo et al.2011; Williams et al.2012; Zawiślak et al.2014; Liu et al.2005) as well as genes involved in early tooth development, which disruption may result in tooth agenesis (Tompkins...
22. Lin D, Huang Y, He F, Gu S, Zhang G, Chen Y, Zhang Y: Expression survey of genes critical for tooth development in the human embryonic tooth germ. Dev Dyn 2007, 236:1307–1312. 23. Hu X, Zhang S, Chen G, Lin C, Huang Z, Chen Y, Zhang Y: Expression of SHH signaling...
In only a few studies has the potential importance of this transmembrane polymorphic glycoprotein receptor been examined during tooth-germ development (Nakamura et al., 1995; Nakamura and Ozawa, 1997; Yu and Toole, 1997). These studies were carried out on various species and their results do no...
KovacsCS,ChaussainC,OsdobyP, et al. The role of biomineralization in disorders of skeletal development and tooth formation[J].Nat Rev Endocrinol,2021,17(6): 336-349. doi:10.1038/s41574-021-00488-z. https://www.ncbi.nlm.nih.gov/pubmed/33948016 ...
We identified a novel frameshift mutation of the highly conserved C-terminal domain of MSX1, known as Msx homology domain 6 (MH6), in a Japanese family with non-syndromic tooth agenesis. To investigate the importance of MH6 in tooth development, Msx1 was targeted in mice with CRISPR/Cas ...
Single-cell transcriptomic profiling of tooth organoids driven into amelogenesis-resembling differentiation.aExperimental overview of the scRNA-seq analysis. UMAP plot of the integrated DF and organoid samples as indicated. ‘Primary’ means all DF clusters.bProjection of indicated genes on the integrated...