1c). Within-subject variation over time was consistently lower than between-subject variation, both in organismal composition and in metabolic function (Fig. 1d). The uniqueness of each individual’s microbial community thus seems to be stable over time (relative to the population as a whole),...
This structure and function analysis performed on the human ribosome using a variety of drug candidates provides important insights for the development of new antibiotics. Results Structural analysis of the human 80S/CHX complex Human ribosomes were prepared as described11, incubated with CHX to form...
1). These factors must be considered individually and collectively when correlating changes in the microbiome structure and function to human health and disease. Fig. 1 Antibiotic perturbation to the microbiome needs to be considered in context. Certain factors are important to consider throughout ...
massively (up to 3,214-fold) induced by the stress. While the inclusion of novel exons can interrupt and truncate the canonical open reading frames (ORFs), we show that such transcripts can function as bi-cistronic mRNAs. Altogether, these results argue for widespread presence of yet unannotate...
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We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media. By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some...
This procedure was chosen to reduce the stress on the patient and was approved by the ethics review board. No personalized notes were made to reduce traceability and maintain patient confidentiality. The studies adhered to the rules of the Helsinki declaration. Animal presentations are from archival...
Crystal structure of the β2 adrenergic receptor–Gs protein complex. Nature 477, 549–555 (2011). Article CAS PubMed PubMed Central ADS Google Scholar Rosenbaum, D. M. et al. GPCR engineering yields high-resolution structural insights into β2-adrenergic receptor function. Science 318, 1266...
Ligand recognition and G protein coupling of the human itch receptor MRGPRX1 Article Open access 17 August 2023 Structure, function and pharmacology of human itch GPCRs Article 17 November 2021 Determination of key residues in MRGPRX2 to enhance pseudo-allergic reactions induced by fluoroquino...
Cancer is a public health problem occupying the first and second place in number of deaths in developed and developing countries, respectively. Since the last century, the relationship between infection and cancer has been established in animals and more