Human serum albumin (HSA) is the most prominent protein in plasma. The three-domain design of HSA provides a variety of binding sites for many ligands, including heme, bilirubin and drugs. Here, we report the effect of new generation, non-steroidal anti-inflammatory drug (NSAID) meloxicam on...
Human serum albumin Albumin PDB rendering based on 1e7h. Available structures: 1ao6, 1bj5, 1bke, 1bm0, 1e78, 1e7a, 1e7b, 1e7c, 1e7e, 1e7f, 1e7g, 1e7h, 1e7i,
Albumin represents the major fraction of the human serum proteins with a concentration in the blood between 35 and 50 g/L and a molecular weight of 65 kDa. HSA has a lifetime of 19 days and is stable in the pH range between 4 and 9. It provides two binding sites for ...
albumin bindingPhysiological processes rely on initial recognition events between cellular components and other molecules or modalities. Biomolecules can have multiple sites or mode of interaction with other molecular entities so that a resolution of the individual binding events in terms of spatial ...
20: Mapping of the High-Affinity Bilirubin-Binding Site of Human Serum AlbuminPediatric Research publishes original papers, invited reviews, and commentaries on the etiologies of diseases of children and disorders of development, extending from molecular biology to epidemiology. Use of model organisms ...
We show here for the first time that HSA possesses two nucleic acid-(NA) binding sites and we estimated the relative contributions of the nucleotide links of (pN) n to their total affinity for these binding sites with higher and lower affinity for NAs. T
At constant albumin concentration (in the in vivo range) and various l-tryptophan concentrations, binding was greater in serum, with an apparent association constant ( k) equal to 4.88 × 10 4 I/mole and the number of binding sites ( n) equal to 0.62. The corresponding kinetic parameters ...
Circular dichroism (CD) and Raman spectroscopy were employed in order to locate a camptothecin (CPT)-binding site within human serum albumin (HSA) and to identify protein structural transformations induced by CPT binding. A competitive binding of CPT and 3'-azido-3'-deoxythymidine (a ligand occup...
Liraglutide's protracted action highly depends on its capacity to bind to albumin via its palmitic acid part. However, in diabetes, albumin can undergo glycation, resulting in impaired drug binding. Our objective in this study was to assess the impact of human serum albumin (HSA) glycation on ...
Curry, “Lessons from the crystallographic analysis of molecule binding to Human Serum Albumin,” Drug Metab Pharmacokinet 24(4):342-357 (2009). Curry et al., “Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites,” Nat Struct Bi...