Here, we present the design and analysis of the results from the competition Human Protein Atlas – Single-Cell Classification hosted on the Kaggle platform. This represents a crowd-sourced competition to develop machine learning models trained on limited annotations to label single-cell protein ...
24k Accesses 77 Citations 107 Altmetric Metrics details Abstract The development of single-cell and spatial transcriptomics methods was instrumental in the conception of the Human Cell Atlas initiative, which aims to generate an integrated map of all cells across the human body. These technology ...
To the Editor: We report on the launch of version 7 of the Human Protein Atlas with subcellular localization data and expression data for all major human tissues and organs. A milestone has been achieved with the inclusion of expression data for >50% of the human protein-coding genes. The ...
HPA (https://www.proteinatlas.org/humanproteome/tissue) was used for extracting images of protein stainings with antibodies on human tissues. BCR and TCR analysis from VDJ-data VDJ analysis was done with Scirpy 0.6.0 (https://icbi-lab.github.io/scirpy/)111. For TCR data, clonotypes ...
The HPP Ab Resource Pillar, ostensibly led by the Human Protein Atlas (HPA; www.proteinatlas.org), was initiated in 2003 and uses Ab-based strategies to analyse spatio-temporal aspects of the proteome39. Linking the identification of proteins with ‘real-time’ localization at tissue, cell and...
Protein-protein interaction (PPI) networks (interactome networks) have successfully advanced our knowledge of molecular function, disease and evolution. While much progress has been made in quantifying errors and biases in experimental PPI datasets, it r
8897 Accesses 19 Citations 16 Altmetric Metrics details Abstract In modern biology, the correct identification of cell types is required for the developmental study of tissues and organs and the production of functional cells for cell therapies and disease modeling. For decades, cell types have been...
Ouyang, W., Winsnes, C.F., Hjelmare, M.et al.Analysis of the Human Protein Atlas Image Classification competition.Nat Methods16, 1254–1261 (2019). https://doi.org/10.1038/s41592-019-0658-6 Download citation Received30 April 2019 ...
Although plasma proteins have important roles in biological processes and are the direct targets of many drugs, the genetic factors that control inter-individual variation in plasma protein levels are not well understood. Here we characterize the genetic architecture of the human plasma proteome in hea...
This was further filtered for putative secreted protein-coding genes using the Human Protein Atlas as a reference. Gene–gene co-occurrence and epicardial gene module constructionCells annotated as epicardium after clustering were isolated in a new matrix, and a set of epicardial features for ...