Here, we present the design and analysis of the results from the competition Human Protein Atlas – Single-Cell Classification hosted on the Kaggle platform. This represents a crowd-sourced competition to develop machine learning models trained on limited annotations to label single-cell protein ...
We report on the launch of version 7 of the Human Protein Atlas with subcellular localization data and expression data for all major human tissues and organs. A milestone has been achieved with the inclusion of expression data for >50% of the human protein-coding genes. The main new feature ...
Human Protein atlas: https://www.proteinatlas.org/ Tabula Sapiens: https://tabula-sapiens-portal.ds.czbiohub.org/ UCSC Cell Browser: https://cells.ucsc.edu/ Supplementary information Supplementary Information Glossary Cell state Intermediate, hybrid or transitional state acquired by the cell types ...
Ouyang, W., Winsnes, C.F., Hjelmare, M.et al.Analysis of the Human Protein Atlas Image Classification competition.Nat Methods16, 1254–1261 (2019). https://doi.org/10.1038/s41592-019-0658-6 Download citation Received30 April 2019 ...
11k Accesses 26 Citations 5 Altmetric Metrics details This article has been updatedAbstract Protein secretory pathway in eukaryal cells is responsible for delivering functional secretory proteins. The dysfunction of this pathway causes a range of important human diseases from congenital disorders to ...
Protein-protein interaction (PPI) networks (interactome networks) have successfully advanced our knowledge of molecular function, disease and evolution. While much progress has been made in quantifying errors and biases in experimental PPI datasets, it r
Citation: Tran, A.N., Dussaq, A.M., Kennell, T. et al. HPAanalyze: an R package that facilitates the retrieval and analysis of the Human Protein Atlas data. BMC Bioinformatics 20, 463 (2019) https://doi.org/10.1186/s12859-019-3059-zBack...
Although plasma proteins have important roles in biological processes and are the direct targets of many drugs, the genetic factors that control inter-individual variation in plasma protein levels are not well understood. Here we characterize the genetic architecture of the human plasma proteome in hea...
The HPP Ab Resource Pillar, ostensibly led by the Human Protein Atlas (HPA; www.proteinatlas.org), was initiated in 2003 and uses Ab-based strategies to analyse spatio-temporal aspects of the proteome39. Linking the identification of proteins with ‘real-time’ localization at tissue, cell and...
We defined genes likely to be expressed in many tissues as those having an expression level above the median for a given tissue in more than half of the tissues in the Human Protein Atlas (https://www.proteinatlas.org/). To compare the enrichment of genes defined as highly pleiotropic in...