Here we describe the Geographic Population Structure (GPS) algorithm and demonstrate its accuracy with three data sets using 40,000–130,000 SNPs. GPS placed 83% of worldwide individuals in their country of origin. Applied to over 200 Sardinians villagers, GPS placed a quarter of them in ...
so a vaccine would need to be effective for 70% of the population. 22.5% will help but will not end the pandemic. However, natural immunity from recovery has been building. Unlike vaccine immunity based only on who was given or will take the vaccine, natural immunity is based on the viru...
Repetitive DNA sequences playing critical roles in driving evolution, inducing variation, and regulating gene expression. In this review, we summarized the definition, arrangement, and structural characteristics of repeats. Besides, we introduced diverse
Language allows us to express needs, feelings and achieve our communication goals. Society changes and grows more complex over time; thus, language must evolve and adapt itself to the new needs of its population. As a consequence, this evolution leads to changes, creation and vanishing of expres...
First, due to the COVID-19 epidemic, the collection of population samples could not be conducted smoothly, thus the sample size is small and it will need to be amplified in the future. Second, the causalities among synaptic plasticity and KP, colon barrier integrity, and KP should be ...
The human reference genome is still incomplete, especially for those population-specific or individual-specific regions, which may have important functions. Here, we developed a HUman Pan-genome ANalysis (HUPAN) system to build the human pan-genome. We a
Moreover, the percentage of the NKX6-1-positive population was regulated by the duration of RA/FGF10 induction and inhibition of BMP and SHH signaling pathways (Nostro et al., 2015). Furthermore, dissociation of densely formed definitive endoderm cells and re-plating them at low density ...
These studies demonstrate the significant transient impact that antibiotics can have on the human microbiota but the consequences of this impact at a population scale and over longer time periods are still relatively under-explored. There are clear geographic differences in the frequency and type of ...
This population also highly expressed CLU, a marker for intestinal revival stem cells that has previously been described54. Endothelial lineage cells (PECAM1, CDH5) were subdivided into arterial (GJA4, HEY1, HEY2, EFNB2), venous (ACKR1, VWF) and lymphatic endothelium (PROX1, LYVE1, CCL21...
(for example, Maltese or Hawai'ian); and low- or under-resourced languages, which may be spoken by a large population but are under-represented digitally (for instance, Quechua). These languages share certain characteristics in common; the most pertinent is sparse data and a lack of resources...