expanding our understanding of the role of population demographic history and natural selection in shaping genetic and phenotypic diversity in humans. Future work is needed to dissect the genetic architecture of skin color adaptation in numerous ethnic minority groups around the world, which ...
with an aspired goal of producing a high-quality pangenome reference representing over 99% of human genetic diversity for minor alleles of at least 1% or higher frequency in the human population6. We estimate that
which were found homozygous in all affected individuals within the same family and present in < 20 homozygous carriers in gnomAD were analyzed. For the second strategy, shared variants were filtered out if they met one or
The early hunter-gatherer communities gave way to populations with northern morphometric affinities, seen at Neolithic and Bronze-Iron Age population samples in eastern Eurasia. The prevailing hypothesis for the origin of the "second layer" and the spread of its descendants across much of East Asia...
A similar positive conclusion was detected in the subgroup analysis of the “population-based control, PB” under the allelic, carrier, homozygotic and recessive models (Table 3, P < 0.05, OR > 1). For the PCR-RFLP subgroup analysis, we only observed an increased risk of cancer ...
1000 years and many generations later, the population is expanding somewhat, and someone from this newest generation who seems a lot more intelligent than most, realizes that mud after it dries becomes very hard but in its wet form, it is very pliable. So he begins constructing a mud hut ...
Using this μ and θ maximum likelihood (θML), we estimated the effective population size parameter (Ne). With these assumptions, the coalescence time, scaled in 2Ne units, was converted into years. For the coalescence process, 106 simulations were performed. A third TMRCA was calculated as ...
are unlikely to occur at the same position in multiple single cells2. Instead, a strand state change at the same genomic position in a population of cells is indicative of a different process other than DSB (such as a genomic SV or genome misassembly)13,44,45. Observing a complete switch...
Given the profound effect of PPIs on the gut microbiome and the fact that over 11% of population in The Netherlands and other European countries are using PPIs on prescription (not including over the counter use of PPIs) implies a major PPI-dependent influence on the gut microbiome taxonomy ...
[9]. Validation of disease co-prevalences often requires laborious population studies. According to the results of this work, the decision to mount a study could be supported by testing hypotheses about disease associations computationally. Simultaneously, shared causal components provide insight into ...