The deep population history of East Asia remains poorly understood owing to a lack of ancient DNA data and sparse sampling of present-day people1,2. Here we report genome-wide data from 166 East Asian individuals dating to between 6000 bc and ad 1000 and 46 present-day groups. Hunter-gathe...
The node duplication rate can be parameterized in multiple ways. In the simplest model, we assume that the duplication rate for all nodes is the same,δi=δ. We will further refer to this model as the Uniform Copying Model or UCM (Fig.3). The connected component size distributions in net...
Primates had a unique oligodendrocyte population (Oligo SLC1A3 LOC103793418 in marmosets and Oligo L2-6 OPALIN MAP6D1 in humans) that was not a distinct cluster in mice (Extended Data Fig. 5c). Surprisingly, this oligodendrocyte population clustered with glutamatergic neurons (Extended Data Fig....
Prolonging human life has increased the size of the human population. Many people alive today would have died of childhood diseases if they had been born 100 years ago. Because more people live longer there are more people around at any given time. In fact it is a decrease in death rates...
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Our analysis expands significantly upon existing data that quantify mutation burden in cancer [28, 51], providing data for many previously undescribed cancer types. We provide new data supporting rational expansion of the patient population that could benefit from immunotherapy and which will allow ...
in individuals with OFC than in the population without these birth defects, although this evidence is restricted to the upper jaw. The prevalence of TA in and outside the cleft area, as well as its location in the upper versus lower jaw, has been reported to be significantly higher in ...
Upper gastrointestinal (GI) disorders and abdominal pain afflict between 12 and 30% of the worldwide population and research suggests these conditions are linked to the gut microbiome. Although large-intestine microbiota have been linked to several GI di
Figure 1: Analyses of population differentiation. (a,b) Genic enrichment among alleles in different bins of population differentiation between (a) CHB or (b) GBR and YRI. The bootstrap 95% confidence interval is shown in yellow, and the level of significance of the bias in genic enrichment ...
In addition, we manually curate the genotypes to check that the data from each individual has sensible population genetic properties, by looking for potential outliers based on ADMIXTURE27 and principal components analysis28. Curation of metainformation and integration of ongoing community feedback ...