Large-scale genome-wide enrichment analyses identify new trait-associated genes and pathways across 31 human phenotypes. Nat. Commun. 9, 4361 (2018). Article PubMed PubMed Central Google Scholar Wang, Q. et al. A Bayesian framework that integrates multi-omics data and gene networks predicts ...
et al. The longevity associated sh2b3 (lnk) genetic variant: selected aging phenotypes in 379,758 subjects. J. Gerontol. A. Biol. Sci. Med. Sci. https://doi.org/10.1093/gerona/glz191 (2019). Sun, B. B. et al. Genomic atlas of the human plasma proteome. Nature 558, 73–79 (...
21,22]. This led us to posit that the bacterial communities of these two anatomical sites may be connected [14]. A recent 16S rRNA gene sequencing survey
those of human tissues, and found that cattle rumen showed the highest similarity with vagina, esophagus, and skin in humans compared to other tissues, which was due to the high enrichment of epithelial cells in these tissues. Meanwhile, cattle horns showed a low correlation of gene expression ...
As a first test of the medical validity of the HPO annotations for common-disease phenotypes, we visualized the network of phenotypic similarity of a subset of 1,678 diseases, such as “nervous system disease” (DOID: 863) or “respiratory system disease” (DOID: 1579), belonging to 13 ...
Culture variabilities of human iPSC-derived cerebral organoids are a major issue for the modelling of phenotypes observed in Alzheimer’s disease. Stem Cell Rev Rep. 2021;18:718–31. Article PubMed Google Scholar Peterson LJ, Flood PM. Oxidative stress and microglial cells in Parkinson’s ...
Blood banks have difficulty in finding suitable blood components for patients with rare blood types such as Jr(a-) and Dphenotypes. Jra is an extremely high-incidence antigen seen in all populations. The incidence of Jr(a-) phenotype is only 0.03 to 0.12 percent even in Japanese population,...
insertions causing cells containing them to be depleted during growth would represent insertions with a negative effect on cellular fitness and those enriched — a positive effect. Precise mapping of cellular integration events allows for the connection of the integration sites to the phenotypes of inte...
The identified candidate enhancers are enriched near genes implicated in craniofacial human phenotypes, with 9 of the top 15 terms directly related to craniofacial or eye-associated phenotypes (Fig. 2a, and Supplementary Data 6), including midface retrusion, reduced number of teeth, and abnormality...
Human orthologs of SST and SA genes were used in DAVID 6.8 [30] to test for enrichment of Genetic Association Database (GAD) disease phenotypes [31], KEGG Pathways [32], and Gene Ontology (GO) enrichments. STRING 11.0 protein interaction network analysis [33] was conducted on the subsets...