It is not fixed to a single localized organ in the body, but rather is made up of numerous specialized cell types that must adaptably organize their intercellular connections to respond to pathogens and other threats wherever they may appear. We provide a systematic and quantitative view of the...
Integumentary SystemThe integumentary system is an organ system consisting of the skin, hair, nails, and exocrine glands. WE'VE BEEN FEATURED IN PUBLICATIONS SUCH AS: No spam! Yourprivacyis important to us.
including circulating blasts in the PB (Supplementary Fig.4h) and blast infiltration into the spleen and liver (Fig.3cand Supplementary Fig.4h).CRISPRMLL-AF4+ mice also had central nervous system (CNS) disease, with extensive parameningeal blast cell infiltration (Fig.3d); a key clinical featu...
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To our knowledge, this is the first study evaluating the effects of repeated whole cigarette smoke and whole EVP aerosol exposure to a 3D lung model at the ALI. Our results add to the growing body of scientific literature supporting the THR potential of EVPs relative to combustible cigarettes ...
Epithelial regeneration is essential for barrier maintenance and organ function [36, 37]. Therefore, specific markers of intestinal stem cells (ISCs) were investigated. As depicted in Fig. 11E, CRS led to significantly decreased mRNA expression of ISCs, while Ri. intervention resulted in a pronounc...
Organ-on-a-chip (OOC) provides microphysiological conditions on a microfluidic chip, which makes up for the shortcomings of traditional in vitro cellular culture models and animal models. It has broad application prospects in drug development and screening, toxicological mechanism research, and precision...
Then, to gain insight into the specific networks affected by SMF exposure, which were not obvious by simple inspection of the genes involved, the microarray data was subject to software analysis and signaling networks consistent with tissue- or organ-level responses to magnetic exposure (that ...
Liver transplantation remains the only curative treatment for end-stage liver diseases. Unfortunately, there is a drastic organ donor shortage. Hepatocyte transplantation emerged as a viable alternative to liver transplantation. Considering their unique
T.M. Consortium, Tabula Muris Consortium, Overall coordination, Logistical coordination, Organ collection and processing, Library preparation and sequencing, Computational data analysis, Cell type annotation, Writing group, Supplemental text writing group, Principal investigators Single-cell transcriptomics of ...