progenitor cells, and terminally differentiated cell types. By modifying the combination of growth factors and cell isolation procedures, researchers can rapidly alter the 3D culture system to generate multiple kinds of human normal and cancerous ...
Much has been learned about the diversity and distribution of human-associated microbial communities, but we still know little about the biology of the microbiome, how it interacts with the host, and how the host responds to its resident microbiota. The Integrative Human Microbiome Project (iHMP,...
It must be noted, however, that it is ques- tionable whether the microbiota alterations are really cause or consequence of a specific disease; however, it has been proven a direct relationship between alterations in microbiota composition and diversity and high risk to develop specific diseases as...
coagulans can regulate host symbiotic microbiota and inhibit the growth of pathogenic bacteria. Lastly, due to its ability to normalize both the quantitative parameters of the immune system and immune cells’ functional activity, B. coagulans can significantly benefit the host immune system. Due to ...
UC San Diego HMI and Novonesis are committed to eventually bringing in other academic and industry partners to develop a strategic framework that identifies knowledge gaps and outlines a robust path to close them. “There are so many aspects we don’t fully understan...
of the gut microbiome on Group 1 ILC function have demonstrated that murine splenic NK cells from germ-free or antibiotic- treated mice had reduced IFNγ production and impaired cytotoxic function,26 and was shown to be dependent on the interaction between the microbiota and mononuclear phagocytes...
Alteber Z, Sharbi-Yunger A, Pevsner-Fischer M, Blat D, Roitman L, Tzehoval E, Elinav E, Eisenbach L (2018) The anti-inflammatory IFITM genes ameliorate colitis and partially protect from tumorigenesis by changing immunity and microbiota. Immunol Cell Biol 96:284–297. https://doi.org/10...
Gut microbiota also influences the development of their host’s organs. Germ-free animals display incomplete development of the intestinal mucosal barrier and other organs. Their intestinal epithelial cells (especially the villus) only develop completely after they have normal microbiota.Footnote12 ...
Innate lymphoid cells (ILCs) are largely tissue-resident, mostly described within the mucosal tissues. However, their presence and functions in the human draining lymph nodes (LNs) are unknown. Our study unravels the tissue-specific transcriptional profi
Asthma is a chronic inflammatory disorder of the airways. Disease presentation varies greatly in terms of cause, development, severity, and response to medication, and thus the condition has been subdivided into a number of asthma phenotypes. There is st