HUMAN DNAMITOCHONDRIAL DNANUCLEOTIDE sequencingMEDICAL geneticsThe mitochondrial genome (mtDNA) is of interest for a range of fields including evolutionary, forensic, and medical genetics. Human mitogenomes can be classified into evolutionary related haplogroups that provide ancestral information and pedigree...
Human mitochondrial DNA haplogroup U is among the initial maternal founders in Southwest Asia and Europe and one that best indicates matrilineal genetic continuity between late Pleistocene hunter-gatherer groups and present-day populations of Europe. While most haplogroup U subclades are older than 30 ...
The mitochondrial DNA (mtDNA) control region is believed to play an important biological role in mtDNA replication. Large deletions in this region are rarely found, but when they do occur they might be expected to interfere with the replication of the molecule, thus leading to a reduction of m...
Cited by (1) Origin and spread of human mitochondrial DNA haplogroup U7 2017, Scientific ReportsView full text Copyright © 2015 Elsevier Ltd. All rights reserved. Recommended articles Using mouse genetics to understand human skeletal disease Bone, Volume 126, 2019, pp. 27-36 Scott E. Youlten...
Concept for estimating mitochondrial DNA haplogroups using a maximum likelihood approach (EMMA) 2013, Forensic Science International: Genetics Citation Excerpt : Haplogrouping of mtDNA sequences has been greatly simplified with the provision of Phylotree, which is widely accepted as “mitochondrial haplogro...
Salomao S.R., Belfort R.Jr., Griffiths P., Man P.Y., de Coo R.F., Horvath R., Zeviani M., Smeets H.J., Torroni A., Chinnery P.F. 2007. Clinical expression of Leber hereditary optic neuropathy is affected by the mitochondrial DNA-haplogroup background.Am. J. Hum. Genet.81, ...
(Supplementary Fig.1, Supplementary Data1). According to the database of polymorphilic mutations in human mtDNA, this variation is derived from A12180T mutation in a type of haplogroup A2 [GenBank accession number KJ923817.1 (ref.67)], suggesting that this heteroplasmy for this mutation is ...
2010 HaploGrep: a fast and reliable algorithm for automatic classification of mitochondrial DNA haplogroups www.haplogrep.uibk.ac.at doi: 10.1002/humu.21382 van Oven M, Kayser M. 2009. Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation. Hum Mutat 30(2):E386–E...
Updated human mitochondrial phylogeny. The left phylogram shows the base binary tree with its associated branch lengths (note the long Neanderthal and Altai clades next to L0). The right cladogram presents the aggregate bootstrap consensus and locates the main haplogroups as defined by MITOMAP's...
Furthermore, the data suggest eastern introduction of farmer-related haplogroups into Finland, contradicting contemporary genetic patterns in Finns.doi:10.1038/s41598-019-51045-8Sanni verstiKerttu MajanderElina SalmelaKati SaloPivi OnkamoScientific Reports...