Combining multiple measurement modalities makes it possible to dissociate multiple biological processes that progress indepen- dently over the lifespan. Consistent with the retrogenesis hypothesis, in each fascicle the rate of R1 development as the brain approaches maturity closely matches the rate of ...
Organoids originating from adult stem cells model important aspects of human physiology and have applications in research related to genetic disorders, infectious disease, cancer, regenerative medicine and drug discovery4. However, they are epithelial-only structures, whereas native organs comprise multiple...
Large-scale genome-wide association studies have recently identified many loci that influence key human ageing traits, including lifespan. Multi-trait loci have been linked with several age-related diseases, suggesting shared ageing influences. Mutations that drive accelerated ageing in prototypical ...
The four temperament dimensions describe and evaluate emotional coping and reactions during development across the lifespan. The three character dimensions predict differences and challenges in the individual self-concept consisting of attitudes, values and goals which form coping strategies to their ...
The current AI tools are creating a great deal of conversation and speculation about the lifespan of higher education, and educational models more generally. These worries are not new. Debates about the impact that technological innovations might have on the ability of students to learn have a ...
The fungal component of the human gut microbiome, also known as the mycobiome, plays a vital role in intestinal ecology and human health. However, the overall structure of the gut mycobiome as well as the inter-individual variations in fungal composition
Furthermore, the prudency on the definition of longevity phenotype has also allowed us to propose components of exposome causally linked to longevity more precisely since the definition of outcome was limited to mortality or parental life span in previous MR [2, 8]. Meanwhile, as with all MR ...
In light of the scope and ambition of such an international initiative, the HCA Ethics Working Group (EWG) has been working to build a solid foundation to address the complexities of data collection and sharing as part of Atlas development. Indeed, a particular challenge of the HCA is the ...
Hypertension is the leading modifiable risk factor associated with an increased cardiovascular disease and mortality rate [1]. Different guidelines for the management of hypertension have constantly acknowledged that the prevalence of hypertension is different between men and women across the lifespan [2,...
In early development stages throughout embryogenesis, vitamin A (retinol form) stimulates the activation of the transcription factor Hoxa1 which is important for segmentation and patterning of the hindbrain area as shown in Table1[20,21]. During prenatal and postnatal life, it is well-known that...