Extrapolation coefficients for risk assessment are to be used with caution; an intra-species extrapolation factor of 10 explained the relationship between acute (LC 50) and chronic (NOEC) ecotoxicity, whereas it was not suitable for inter-species extrapolation. The method is applied to a case ...
relationship between all the analyzed cell lines (CCLE + HPA) by Spearman’s correlation and found that 33 pairs of the common cell lines between CCLE and HPA were clustered together, except for a single cell line, U-251MG (Supplementary Fig.3a). The high correlation of the transcriptom...
A severe decline in child births has occurred over the past half century, which will lead to considerable population declines, particularly in industrialized regions. A crucial question is whether this decline can be explained by economic and behavioural factors alone, as suggested by demographic repor...
The cellular landscape of the human intestinal tract is dynamic throughout life, developing in utero and changing in response to functional requirements and environmental exposures. Here, to comprehensively map cell lineages, we use single-cell RNA seque
According to the ‘bad luck hypothesis’78, the discrepancy in cancer rates could be explained by differences in the stem cell dynamics of the two tissues, with more stem cells dividing more rapidly carrying a higher risk of progressing to cancer. We only detect moderate differences in the ...
Although elaborately explained the roles of the brain derived neurotransmitter in terms of their neuroactivities, the function of KP metabolites in the gastrointestinal (GI) tract still remains poorly understood [56]. To unravel the underlying relationships among KP metabolism, microbial composition and ...
However, the finding for human cells has been challenged by several authors [13,68], arguing that the slowness in disappearance of label from the blood could be explained by a ‘slow neutrophil compartment’ in the bone marrow and a ‘fast compartment’ in peripheral blood. Indeed, this ...
Overall, the evidence implies that accumulation of specific capital is an important ingredient of the typical employment relationship, and of life-cycle earnings and productivity as well. Continuation of these relationships has substantial specific value for workers. 展开 ...
participants provided written informed consent after all procedures were fully explained. Forty-one participants were enrolled, of whom two were excluded due to inability to tolerate the 7-T MRI scan, eight voluntarily discontinued because of the time demands of the study, and four were excluded ...
Major variables explained above (i.e. measured substance, age group, country, and sampling year) created a high data categorization. For this reason, other variables which were considered comparatively less important for our analysis, for example the gender, area (urban, suburban), or the sample...