Maintenance of inflammation may be explained by the resistance of local effector cells, previously demonstrated in both JIA and RA17,62,63. In mice, functional specialization of Treg cells towards Th1 inflammation by upregulation of T-bet is described as essential to prevent Th1 autoimmunity9,10....
fat-soluble vitamins requirements is presented for the first time across the human life cycle beginning from fertility, pregnancy, adulthood, and senility with an extensive assessment ofthe interactions among them and their underlying mechanistic actions. The influence of sex for each vitamin is also ...
The cellular landscape of the human intestinal tract is dynamic throughout life, developing in utero and changing in response to functional requirements and environmental exposures. Here, to comprehensively map cell lineages, we use single-cell RNA seque
A severe decline in child births has occurred over the past half century, which will lead to considerable population declines, particularly in industrialized regions. A crucial question is whether this decline can be explained by economic and behavioural factors alone, as suggested by demographic repor...
This may be explained by the combined findings that (i) peroxisomes contain relatively large amounts of heme- and non-heme iron-containing enzymes [72], and (ii) ascorbic acid can reduce transition metals, and this may in turn lead to the generation of free radicals through the Fenton ...
Conspicuous modifications of the biophysical properties of the membrane indeed occur continuously during the cell life span as a function of the cell cycle, cell growth, cell motility, or cell activation state (60). For simplicity, we may consider that at steady state conditions, molecular motors...
This could be partly explained by the fact that education was a long-term investment, the benefits of which took some time to become visible. Education could play a decisive role in the post-war reconstruction by restoring the productive structure if more resources were devoted to the equipment...
Although elaborately explained the roles of the brain derived neurotransmitter in terms of their neuroactivities, the function of KP metabolites in the gastrointestinal (GI) tract still remains poorly understood [56]. To unravel the underlying relationships among KP metabolism, microbial composition and ...
For the exactly solvable GRMC, this can be explained by noting that \(\langle R_{mn}\rangle \approx r_{\mathrm{c}}P_{mn}^{ - 1/3}\) for small Pmn. Because Pmn appears in the denominator, any uncertainty in rc is amplified by Pmn, especially when Pmn is small. Heterogeneity ...
Importantly, further analysis of maternal specimens obtained during the initial, uncontrolled trial suggested that some benefit that was ascribed to the hyperimmune globulin could be indirect and explained by its anti-inflammatory activity on the placentas from infected mothers [358,359,360,361,362,36...