Recombinant Human IFN-λ1/IL-29 (Recombinant Human Interferonλ1/Interleukin-29; rHuIFN-λ1/IL-29);重组人干扰素1/白细胞介素29 Synonyms IFN-lambda 1; cytokine Zcyto21; IFNL1; IFN-lambda-1; IL-29; interferon lambda-1; interferon, lambda 1; interleukin 29 (interferon, lambda 1); interleu...
IFN-γ was secreted by the peripheral leukocytes of both patients in response to BCG alone or BCG plus IL-12, and its levels in whole blood were similar to those of healthy local and travel controls (Figure 4A). Consistent with the results for whole blood, the stimulation of PBMCs from ...
IFNL1 重组蛋白;高活性/Recombinant human IFNL1 protein Tnf 重组蛋白;高活性/Recombinant human Tnf protein GH1 重组蛋白;高活性/Recombinant human GH1 protein Prl 重组蛋白;高活性/Recombinant human Prl protein ME2 重组蛋白;高活性/Recombinant human ME2 protein ...
PD-L1 (B7-H1) and PD-L2 (B7-DC), that are primarily expressed on dendritic cells (DCs) and myeloid lineage cells but can also be expressed on tumors, particularly in the case of PD-L18. Furthermore, PD-L1 expression can be increased in the tumor microenvironment by IFNγ, a cytokine...
In these experiments, we hypothesized that inhibitory ligands expressed on HIV MDSC are involved in controlling CMV specific IFNγproduction from CD4+ T cells. We first examined the surface expression of PD-L1, B7-H3, PD-L2, ICOS-L and B7-H4 on HIV MDSC and compared the expres- sion...
Results To overcome this limitation, we have developed an inter-species cross-reactive PD-1 antibody, GNUV201, by utilizing an enhanced diversity mouse platform (SHINE MOUSE™). GNUV201 equally binds to human PD-1 and mouse PD-1, equally inhibits the binding of human PD-1/PD-L1 and mo...
The present study shows that myeloma cells are able to induce an up-regulation of RANKL and a down-regulation of IFN-γ secretion by T lymphocytes at least in part through the mediation of IL-7. Our results confirm the critical role of the RANKL molecule in osteoclast activation and the po...
S4). These results provided insight into the clinical applicability of IMRCs, especially with regards to their complete loss of pluripotency and their gain in hyper-immunomodulatory potential. IMRCs treated with IFN-γ show hyper-immunomodulatory potency To test the immunomodulatory capacity of IMRCs,...
results highlight the involvement of lung-related biological pathways in the development of severe COVID-19. Several other loci show no previously documented genome-wide significant associations, despite the high significance and attractive candidate genes for COVID-19 (for example,CXCR6,LZTFL1,IFNA...
For example, it has been described that the homozygous deletion of the antibody heavy-chain joining region (JH) gene in chimeric and germ-line mutant mice results in complete inhibition of endogenous antibody production. Transfer of the human germ-line immunoglobulin gene array into such germ-line...