The predicted level of epicardial communication with other heart cell types in each stage was calculated using CellPhoneDB, showing the total volume of communication (d) and clustered epicardial-specific secretions filtered by upregulated genes predicted to interact with all other heart clusters of eith...
Congenital heart defects constitute the most common human birth defect, however understanding of how these disorders originate is limited by our ability to model the human heart accurately in vitro. Here we report a method to generate developmentally rel
Full size image We next identified the functions that may facilitateE. coliadaptation and colonization to these two environmentally different niches by evaluating the predicted functions encoded by the bladder and gut genomes that were both abundant and differentially present (Fig.4C, Additional file2:...
The cutting-edge spatial transcriptomics (ST) technology enables researchers to describe an unbiased map of transcripts over an entire tissue section using spatially barcoded oligo-deoxythymidine microarrays, which has preliminarily been utilized in studies of human fetal heart development and tumor immune...
It was found that while the course and size of individual vessels vary considerably from heart to heart, there is an underlying pattern in the functional arrangement of the vessels. On the basis of this pattern, a new functional classification of coronary arteries is proposed, together with a ...
Urinary creatinine excretion rate and mortality in persons with coronary artery disease: the Heart and Soul Study. In persons with coronary artery disease, low body mass index is associated with greater mortality; however, it is uncertain whether low muscle mass is a ri... H Joachim,Ix,H Ian...
Extracellular vesicles (EVs) play an important role in human and bovine milk composition. According to excellent published studies, it also exerts various functions in the gut, bone, or immune system. However, the effects of milk-derived EVs on skeletal
CNS and Heart: Do the Clinical Symptoms Manifest CoV-2 Infection? Some COVID-19 patients show neurological symptoms (De Felice et al., 2020) such as encephalitis, strokes, seizures, and loss of smell, but it remains unclear whether SARS-CoV-2 can actively infect the CNS. In one case dia...
We calculated log-fold changes of co-expression differences of 100 permutations in 3 different tissues; artery-C, heart-AA, and ad-Gland (Suppl. Fig. 1B). The amount of genes passing an absolute cut-off of log2-fold change over 1 was always higher in co-expression shifts with a sex-...
More specifically, we used an example to illustrate the potential mechanism by which distal GWAS SNPs may impact diseases.HCN4, which is necessary for the cardiac pacemaking process, is specifically expressed in the heart (Fig.6c). We found that several heart-related GWAS SNPs were localized in...