Organoid models of early tissue development have been produced for the intestine, brain, kidney and other organs, but similar approaches for the heart have been lacking. Here we generate complex, highly structured, three-dimensional heart-forming organoi
Activity was reduced by the louder heartbeat sound. Respiration and heart rate were unchanged in all conditions. The results are consistent with the hypothesis that, for newborns, the sound of the heart is an especially effective pacifier.
Finally, we show that epicardioids mimic the multicellular pathogenesis of congenital or stress-induced hypertrophy and fibrotic remodeling. As such, epicardioids offer a unique testing ground of epicardial activity in heart development, disease and regeneration....
Full size image In newborns, only physical health effects offered sufficient data for further analysis. We found no benefits for digestion and heart rate parameters. All other health outcomes (cortisol, liver enzymes, respiration, temperature regulation and weight gain) showed medium to large effects ...
The muscle fibers wrap helically around the heart. At the epicardium, the outer wall, muscle fibers point clockwise-upwards whereas at the endocardium, the inner wall, they point clockwise-downward. We interpolate the fiber and sheet directions from generic fiber orientation illustrations and assign ...
Improvement in contractile activity of the anterior wall in mice administered with day 11 progenitors was also observed, although to a smaller extent (Figure 5G; Video S4). In conclusion, the results demonstrate that the treatment with CVPs restored heart function and attenuated left ventricle (LV...
the question of my destiny: exactly the activity I preach to my students, exactly the activity ...
“first heart field”, and differentiates to form cardiomyocytes during or shortly after the formation of the first somite. The remaining, more caudally located and still proliferating precursors, which form the “second heart field”, start to differentiate at the transition of CS9 into CS1017,...
Hence, increasing Cx43 expression could lead to greater synchronized activity, thus explaining the developmentally-regulated organization of the fiber paths of the developing heart. To test this, we examined protein extracted from fetal hearts ranging from 67–136 DGA, equivalent to the first and ...
activity, and in the next step, they were seeded onto MTFs and combined with a engineered platform in order to create the organ-on-a-chip system for determination of contractility of control versus disease-specific cardiomyocytes [187]. Furthermore, the heart-on-a-chip system enabled ...