New insights into the generation and role of de novo mutations in health and disease Aside from inheriting half of the genome of each of our parents, we are born with a small number of novel mutations that occurred during gametogenesis and postzygotically. Recent genome and exome sequencing ...
IDPs and IDRs were shown to be highly abundant in proteins associated with various human maladies. As the number of IDPs related to various diseases was found to be very large, the concepts of the disease-related unfoldome and unfoldomics were introduced. Novel bioinformatics tools were proposed...
We find the source of life, explore the mystery of the cell, and protect your health with caring service! MORE > Repository Knowledge of cord blood Role of peripheral blood Knowledge of cell 脐带血中含有大量的干细胞,干细胞是生命的种子,它会分化成人体的各种细胞,结出各种不同的果实——血液细胞...
Diet, serving as a vital source of nutrients, exerts a profound influence on human health and disease progression. Recently, dietary interventions have emerged as promising adjunctive treatment strategies not only for cancer but also for neurodegenerative diseases, autoimmune diseases, cardiovascular disease...
Somatic mutations in cancer genomes are caused by multiple mutational processes, each of which generates a characteristic mutational signature1. Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium2 of the International Cancer Genome Consortium (ICGC) and The Cancer Genome At...
Exosomes biology, a rapidly growing field of research, has gained scientists’ attention over the past few decades due to its pivotal role in regulating cellular processes [1]. They transfer biomolecules to target cells and, therefore participate in pathological conditions like cancer [2]. A ...
Unit9HumanBiologyTopicTalk教材分析本课是本单元的起始课,为介绍人类的身体和思维提前做好热身准备,起到了激活主题相关背景知识的作用,并为本单元后面的教学内容做了话题、词汇以及思维的铺垫。教学目标在本课学习结束时,学生能够:1.听取人类生物学相关信息;2.简短评述人的身体和大脑能做的事;3.讨论关于人的身体和...
Lipids are the most abundant but poorly explored components of the human brain. Here, we present a lipidome map of the human brain comprising 75 regions, including 52 neocortical ones. The lipidome composition varies greatly among the brain regions, affe
members of the Sanger Institute zebrafish genome project; the mouse, rat andF. rubripessequencing consortia; Genoscope forT. nigroviridisgenome data; the Ensembl, UCSC, EMBL and GenBank database groups; G. Schuler for information on sequence overlaps; T. Furey for information on RefSeq RNA covera...
Natural, geographical barriers have historically limited the spread of communicable diseases. This is no longer the case in today’s interconnected world, paired with its unprecedented environmental and climate change, emphasising the intersection of evolutionary biology, epidemiology and geography (i.e. ...