including bacteria, yeast, and viruses. Despite this diversity, microbes from the bacterial phyla Bacteroidales and Bacillota (syn. Firmicutes) represent some 90% of the total gut microbiota1. The human gut microbiome has a substantial impact on human health, being...
The genome sequences of many species of the human gut microbiome remain unknown, largely owing to challenges in cultivating microorganisms under laboratory conditions. Here we address this problem by reconstructing 60,664 draft prokaryotic genomes from 3,810 faecal metagenomes, from geographically and ...
The infant gut microbiota may contribute to weight-for-length (WFL) growth through differences in functional capacity to extract energy from non-digestible dietary carbohydrates (CHO). Research is lacking regarding how the infant microbiome may impact WFL growth. We aimed to test whether microbial ...
Human gut microbiome changes during a 10 week Randomised Control Trial for micronutrient supplementation in children with attention deficit hyperactivity disorder Aaron J. Stevens, Rachel V. Purcell, Kathryn A. Darling, Matthew J. F. Eggleston, Martin A. Kennedy & Julia J. Rucklidge Scie...
We created a catalogue of ARGs across both the human microbiome and reference genomes by locating open reading frames (ORFs) on metagenomic assemblies from 8972 human microbiome samples spanning gut (7589), oral cavity (746), skin (380), airway (118), nasal cavity (55), and vagina (83) ...
Gut microbiome composition. The composition of the gut ecosystem is unique to an individual while its functionality is maintained across the population. Pie charts represent the percentage of species (on the left) and microbial metabolic pathways (on the right) present in <1% of the population (...
certain groups. Spearman correlation analysis was performed to analyze the correlation between the gut microbiota and functional characters. Procrustes analysis and Mantel test were used to evaluate the association between 16S data and metagenome data. AllPvalues were two-tailed andPvalues of 0.05 or ...
in the The Environmental Determinants of Diabetes in the Young (TEDDY) study, to characterize the natural history of the early gut microbiome in connection to islet autoimmunity, T1D diagnosis, and other common early life events such as antibiotic treatments and probiotics. The microbiomes of contr...
Humanized gnotobiotic mice will be useful for conducting proof-of-principle "clinical trials" that test the effects of environmental and genetic factors on the gut microbiota and host physiology. Nearly full-length 16S rRNA gene sequences are deposited in GenBank under the accession numbers GQ49...
CrAss-like phages are double-stranded DNA viruses that are prevalent in human gut microbiomes. Here, we analyze gut metagenomic data from mother-infant pairs and patients undergoing fecal microbiota transplantation to evaluate the patterns of acquisition