Several types of T regulatory (Treg) cells have been described in both mice and humans.1, 2, 3, 4 Oral antigen administration or stimulation of CD4+CD25- T cells in vitro in the presence of exogenous transforming growth factor β1 (TGF-β1) induces the outcome of CD4+ T cells able to...
the impact of SAVs and PTMs on protein function is often investigated from a structural angle. However, around 40% of the proteome consists of intrinsically disordered regions (IDRs) that have low sequence complexity10, and over 20%
the impact of SAVs and PTMs on protein function is often investigated from a structural angle. However, around 40% of the proteome consists of intrinsically disordered regions (IDRs) that have low sequence complexity10, and over 20%
NFBD1/MDC1 enhances the radiosensitivity of human nasopharyngeal cancer CNE1 cells and results in tumor growth inhibition Z Wang1, Q Zeng1, T Chen1, K Liao2, Y Bu3, S Hong1 and G Hu*,1 NFBD1 functions in cell cycle checkpoint activation and DNA repair following ionizing radiation (IR...
RPN11 is essential for viability in yeast [192], and its depletion in HeLa markedly elevates cellular poly-Ub levels, impairs proteasome assembly, and inhibits cell growth [189]. 3.5.2. All three proteasomal DUBs play a role in chain editing to assure fidelity of proteolysis The K63-linked...
Genetic generalized epilepsy (GGE) including childhood absence epilepsy, juvenile absence epilepsy, juvenile myoclonic epilepsy (JME), and GGE with tonic–clonic seizures (TCS) (GGE-TCS), is genetically influenced with a two- to four- fold increased risk
The human T-cell leukemia virus type 1 (HTLV-1) was the first retrovirus discovered to be causative of a human cancer, adult T-cell leukemia. The transforming entity of HTLV-1 has been attributed to the virally-encoded oncoprotein, Tax. Unlike the v-onc
CNP has not been used as a diagnostic or therapeutic tool. Several studies suggested potential uses of CNP, such as for the treatment for growth disorders and as a biomarker of growth plate activity. storage Store at -20°C Structure and conformation ...
Sporadic Parkinson’s Disease (sPD) is a progressive neurodegenerative disorder caused by multiple genetic and environmental factors. Mitochondrial dysfunction is one contributing factor, but its role at different stages of disease progression is not fully understood. Here, we showed that neural precursor...
(RosetteSep), and were cultured in presence of growth factors (GM-CSF and IL-4) for 6 days to generated MoDCs, and 200 K-400 K monocytes/well distributed in a six-well plate, and infected immediately with wild type, minor (mfa-1) fimbriae, major (MFI) fimbriae and double (MFB...