Protocol summary and checklist: PeliKine compact human GRANZYME A ELISA kitCatalog No: M
This antibody functions as an ELISA detection antibody when paired with Mouse Anti-Human Granzyme A Monoclonal Antibody (Catalog # MAB29052). This product is intended for assay development on various assay platforms requiring antibody pairs. We recommend the Human Granzyme A DuoSet ELISA Kit (Catalog...
Statistical analyses were conducted using a one-way ANOVA (p < 0.01). Investigation of the antiplasmodial activity of granzyme B P. falciparum 3D7 parasites were maintained in continuous culture as previously described (Trager and Jensen 1976; Zininga et al. 2015). The production of ...
proteases that induce apoptosis in the target cell. Granzymes have also been found to help initiate the inflammatory response by activating macrophages and mast cells when in an extracellular state. Granzymes have also been found to protect the body against the formation of different kinds of ...
Granzyme H is a member of the granzyme family of serine proteases found specifically in the cytotoxic granules of cytotoxic T lymphocytes (CTL) and natural killer (NK) cells (1, 2). Granzyme H’s functions are largely unknown. The more abundant expression of Granzyme H than Granzyme B in ...
Localization and identification of granzymes A and B-expressing cells in normal human lymphoid tissue and peripheral blood Clin Exp Immunol, 100 (1995), pp. 164-172 View in ScopusGoogle Scholar 31 EJ Kunkel, EC Butcher Chemokines and the tissue-specific migration of lymphocytes Immunity, 16 (20...
and mast cells.14 RANTES also has a key function in antitumor15,16 and antiviral17 immune responses, along with perforin and granzyme A.17,18 Even though many researchers have reported the potential of RANTES as a vaccine adjuvant, an optimized and clinically relevant protocol remains to be det...
such as perforin, granzymes, eicosanoids, and histamine (8-10). Up‑regulated LAMP2 at the plasma membrane serves as an indicator of cell activation of CD8+T cells, mast cells, monocytes, and platelets (9-12). LAMP2 is a native ligand for lectins Galectin-1 and Galectin-3 (13‑15...
specific T-cell type 1 and cytotoxic lymphocyte responses where CD4+ T-cells secrete large amounts of cytokines such as IFN-γ and IL2 labeling infected and malignant cells and cytotoxic CD8+ T-cells eliminate infected cells by secreting granzyme B and perforin which lead to cell death [69,...
Besides the perforin/granzyme-based mechanism, the Fas system has been identified as the alternate pathway for CTL‑mediated cytotoxicity. FasL has also been shown to function in immunological privileged sites by killing infiltrating Fas-bearing lymphocytes and inflammatory cells. References Nagata, S....