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A sequencing method in which an entire genome is sequenced from fragmented DNA, producing short (less than 300 bp) sequencing reads at high speed and low cost. Sequence-by-synthesis A sequencing technology used primarily by Illumina, in which a DNA polymerase synthesizes a strand of DNA comp...
California Inc is capable of reads longer than 10 kb5,6, providing an advantage in accessing challenging repetitive regions of the genome7 and in phasing and the detection of complex structural variation8, but relatively high cost and low throughput have so far limited the technology’s ...
The high accuracy, affordable cost of $4400 for sequencing consumables, and scalability of this platform enable complete human genome sequencing for the detection of rare variants in large-scale genetic studies. 展开 关键词: Humans DNA Microarray Analysis Nucleic Acid Amplification Techniques Sequence ...
As the cost of DNA sequencing continues to plummet, there will be many individual whole-genome sequences produced. These DNA sequence data offer many opportunities for analyzing the patterns of human genetic variability and their relationship to disease and normal phenotypic variation, as well as ...
Sequencing has fallen in cost from over $50m a genome at the end of the HGP to a few hundred dollars today, but making it even cheaper and more convenient would allow it to be more widely available.基因组测序的成本已经从HGP2003年结束时的每个基因组的 5000 多万美元下降到今天的几百美元，但...
A fascinating NIH Web page (http://www.genome.gov/sequencingcosts/) describes the declining "cost of determining one megabase (Mb; a million bases) of DNA sequence of a specified quality." Advances in gene sequencing technology, many of which were prompted by NIH, have pushed down the cost...
genome (Figure 1.1b) (seeChapter 9). The ultimate resolution, of course, comes from direct sequence analysis, and a number of new technologies have reduced the cost and improved the throughput of sequencing individual genomes, facilitating comparisons with the reference human genome sequence and ...
DNA can determine where and when genes are expressed, but the full set of sequence determinants that control gene expression is unknown. Here, we measured the transcriptional activity of DNA sequences that represent an ~100 times larger sequence space than the human genome using massively parallel...