In a more surprising finding, the researchers discovered that individual enhancers could affect multiple genes. It was as if one light switch turned on several lights. "We originally had tended to think that one enhancer was affecting one gene, but we found it was really common for one enhance...
Fig. 1. Locus discovery.(A) Manhattan plot of the multivariate GWAS on sulcal depth, with the observed −log10(P value) of each SNP shown on the y axis. The x axis shows the relative genomic location, grouped by chromosome, and the red dashed line indicates the whole-genome significanc...
June 26 2000 — the Human Genome(基因组) Project a great $3 billion 15-year task aimed at drawing the genetic(遗传的) map of humans is now more than 90 percent completed. The scientific and medical communities are very excited about the chances genetic research provides for getting rid of...
Repetitive DNA sequences (repeats) are patterns of nucleic acids that occur in multiple copies throughout the genome1. Both eukaryotic and prokaryotic organisms contain a certain proportion of repeats in the genome2,3,4, particularly mammalians, in which repeats account for 25–50% of their enti...
The company’s partnership with the largest human genome sequencing project in the world will increase scientists’ understanding of genetic diseases and help create new interventions. Here, a look at the breakthroughs that have guided the understanding of the power of DNA. Written by Barbara Brody...
The m6A tag was discovered almost half a century ago, but tools for studying it effectively were until recently limited. The m6A tag regulates the functioning of RNA, the transient molecules that carry instructions from DNA to the cell's protein-making machinery. ...
(> 90% completeness, < 5% contamination), including 781 genomes produced as part of this current effort and 353 genomes from our collection that were previously deposited (Additional file1: Fig. S1, Additional file2: Table S1). The overall qualities of these genome assemblies were high...
Writing in Nature, members of the COVID-19 Host Genetics Initiative3 (www.covid19hg.org) report results of a large human genetic study of SARS-CoV-2 infection. The researchers identify 13 locations (or loci) in the human genome that affect COVID-19 susceptibility and severity....
Recent genome-wide ancient DNA (aDNA) based studies on Southeastern Europe, have shown that Neolithic population from present-day Bulgaria was closely related with the northwestern-Anatolian-Neolithic ancestry that signals the spread of Early farmers across Europe, except for the individuals lived in ...
researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide...