Finally, we analyzed the type, structure, and regulation of repeats in the human genome and their role in the induction of complex diseases. We believe that this review will facilitate a comprehensive understan
The phenomenon of c-value paradox has been discovered, revealing that the number of bases in an organism's genome does not necessarily match the amount of protein-coding region. Humans have approximately 21,000 protein coding genes,44 fewer than those of a rice plant (51,000) and only ...
Researchers found that inhibiting certain genes responsible for protein production in our cells may increase human longevity. Researchers at UCL have discovered that certain genes involved in cellular protein synthesis can impact human lifespan. These genes, previously linked to extended lifespan in model...
He added, “Depending on how you choose to count, most human variation comes from these copy number variable regions that are only going to be unlocked using a pangenome reference. I think it’s absolutely critical that we continue to push the pangenome resource so that the scientific and c...
The human microbiota, especially the gut microbiota, has even been considered to be an “essential organ” [1], carrying approximately 150 times more genes than are found in the entire human genome [2]. Important advances have shown that the gut microbiota is involved in basic human biological...
The m6A tag was discovered almost half a century ago, but tools for studying it effectively were until recently limited. The m6A tag regulates the functioning of RNA, the transient molecules that carry instructions from DNA to the cell's protein-making machinery. ...
They discovered that SNPs associated with the variation in RNA editing function more closely to their respective editing sites and that some of these SNPs are linked to genome-wide association study (GWAS) signals of complex traits or diseases among genetically distinct individuals32. Their work ...
Researchers compared the genome sequences of other animals, such as chimpanzees and platypuses, as well as other eurkaryotic organisms (those whose cells have a nucleus), such as yeast and flat worms. From this comparison, scientists could identify stretches of DNA that have remained largely unch...
Over the last 10 years, there have been enormous developments in DNA sequencing technology, largely through improved automation and huge increases in available computing power, so that now a complete human genome sequence costs in the hundreds of (US) dollars rather than billions of dollars. One ...
Researchers at the John Innes Centre have discovered a gene cluster in wheat that produces triticein, an unexpected isoflavone, paving the way for advances in wheat’s nutritional enhancement and disease resistance. This finding opens new avenues for research into the health benefits and applications...