completion of the Human Genome Project. Completed almost fifty years after the discovery of the DNA double helix and two years after the cloning of Dolly the sheep; no one, just a few years ago would be guessed that in a few short years we would have a complete documented human genome. ...
A scientometric review of genome-wide association studies. Commun. Biol. 2, 9 (2019). Article PubMed PubMed Central Google Scholar Lieberman-Aiden, E. et al. Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science 326, 289–293 (2009). ...
et al. Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity. Proc. Natl Acad. Sci. USA 110, 4768–4773 (2013). Article CAS PubMed PubMed Central Google Scholar Feinstein, Y. et al. F-spondin and mindin: two structurally and functionally ...
S. Human Genome Project: 1998–2003. Science 282, 682–689 (1998). Article ADS CAS PubMed Google Scholar Sanger, F. & Coulson, A. R. A rapid method for determining sequences in DNA by primed synthesis with DNA polymerase. J. Mol. Biol. 94, 441–448 (1975). Article CAS PubMed ...
A metagenome-assembled genome inventory for children reveals early-life gut bacteriome and virome dynamics –Ye Peng- Cell Host & Microbe Lefser: Implementation of metagenomic biomarker discovery tool, LEfSe, in R –Asya Khleborodova – Bioinformatics TechniqueEvaluation of DNA extraction kits for lon...
Diagrammatic view of the process for collecting images for Human Genome Project. 5.1 Development of VHP at IT, CD-ROM, and Internet Level According to the report entitled Visible Human Project Conference Proceedings (Kerr et al., 1996), the editorial report of Slavin (1997), and the papers ...
Upon the completion of the Human Genome Project in 2003, the discrepancy between the number of annotated protein-coding genes and the number of observed human polypeptides reveals the widespread violation of the “one gene–one polypeptide” hypothesis. It is now commonly accepted that in higher eu...
All samples were aligned against the human reference genome GRCh38 using default parameters. After the counts matrices were generated, all fetal samples were treated the same. Poor-quality cells were removed from the read counts matrices in R, retaining only cells with a depth of between 1,000...
This review considers genome-scale evidence on ancient Y chromosome diversity that has recently started to accumulate in geographic areas favourable to DNA preservation. More specifically the review focuses on examples of regional continuity and change of the Y chromosome haplogroups in North Eurasia ...
With the ability to generate reads tens to thousands of kilobases in length with an accuracy approaching that of short-read sequencing technologies, these platforms have proven their ability to resolve some of the most challenging regions of the human genome, detect previously inaccessible structural ...