The Regulation requires pre-approval from or record-filing with the Human Genetic Resources Administration of China (HGRAC) before initiating HGR-related clinical trials. Record-filing is simper and faster, but applicable only when the clinical trial (1) is for the purpose of obtaining a mar...
Multinational companies have been required to obtain pre-approval from, or complete record-filing with, the Human Genetic Resources Administration of China (HGRAC) before they initiate clinical trials or research projects in China, on the grounds that these activities involve China’s human g...
On June 1, 2023, China’s Ministry of Science and Technology (MOST) announced the release of the“Implementation Rules for the Management Regulations of Human Genetic Resources” (the HGR Implementation Rules). The HGR Implementation Rules, scheduled to come into effect on July 1, ...
Between late 2023 and early 2024, the NHC engaged in intensive discussions with experts and industry representatives, resulting in aconsensus on streamlining administration and deregulation. Specifically, the NHC focused on revising rules for the use and management of human genetic resources. The goal ...
Projected prevalence of actionable pharmacogenetic variants and level A drugs prescribed among US Veterans Health Administration pharmacy users. JAMA Netw Open. 2019 Jun 5;2(6):e195345. doi: 10.1001/jamanetworkopen.2019.5345. PMID: 31173123; PMCID: PMC6563578....
Repeated nicotine exposure leads to sensitization (SST) and enhances self-administration (SA) in rodents. However, the molecular basis of nicotine SST and SA and their biological relevance to the mounting genome-wide association study (GWAS) loci of human addictive behaviors are poorly understood. ...
A. Qualitative differences between C57BL/6J and DBA/2J mice in morphine potentiation of brain stimulation reward and intravenous self-administration. Psychopharmacology 208, 309–321 (2010). References 203–205 report some striking phenotypic differences between mouse strains based on genetic variation,...
All protocols followed the Interim Measures for the Administration of Human Genetic Resources, administered by the Ministry of Science and Technology of China. Mice C57BL/6J mice were purchased by Vital River. All experimental procedures of animals were approved by the Animal Committee of the ...
As publicly sharing of the raw genomic data is restricted by the regulation of the Human Genetic Resources Administration of China, detailed results of whole exome sequencing were included in Table S2. Acknowledgments This work was supported by the National Basic Research Program of China (973 ...
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