that the Hoc-like protein might play a role in lysogenized bacterial cells. Despite the potential significance of the Hoc-like gene in the evolution ofMushuvirus mushu, its function remains poorly understood with only homologues of the gene being characterised as enhancing binding to mucus on the...
Functional studies of long noncoding RNAs (lncRNAs) have been hindered by the lack of methods to assess their evolution. Here we present lncRNA Homology Explorer (lncHOME), a computational pipeline that identifies a unique class of long noncoding RNAs (lncRNAs) with conserved genomic locations an...
Kent WJ, Baertsch R, Hinrichs A, Miller W, Haussler D: Evolution's cauldron: Duplication, deletion, and rearrangement in the mouse and human genomes. Proc Natl Acad Sci USA. 2003, 100 (20): 11484-11489. 10.1073/pnas.1932072100. Article CAS PubMed PubMed Central Google Scholar Ashurst...
Awarded “For the development of novel approaches that combine synthetic biology, experimental evolution, and systems biology to address fundamental questions about gene function relevant to health and human disease." The Work...
This complexity reflects the long co-evolution of the HCMV and its host, during which HCMV mechanisms affecting cell and immunological functions emerged to help the virus co-exist with its host. These mechanisms must be considered when investigating the role of the HCMV in cancer. The HCMV ...
2 State Key Laboratory Cultivation Base of Geographical Environment Evolution (Jiangsu Province), Nanjing 210023, China 3 Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application, Nanjing 210023, China 4 Jiangsu Key Laboratory of Crop Genetics and Physiology...
Possibly the precursor of the Hemiascomycetes suffered a major change in the telomerase RNA template region (see also discussion in Brun et al. 1997). We propose a model for the evolution of the telomeric complex in which the ancestral eukaryotic telomeres were composed of TTAGGG repeats and ...
摘要原文 The X-ray crystal structure of relaxin at 1·5Åresolution is reported for the physiologically active form of the human hormone. Relaxin is a small, two-chain polypeptide that is a member of the protein hormone family that also includes insulin and the insulin-like growth factors IGF...
Functional studies of long noncoding RNAs (lncRNAs) have been hindered by the lack of methods to assess their evolution. Here we present lncRNA Homology Explorer (lncHOME), a computational pipeline that identifies a unique class of long noncoding RNAs (lncRNAs) with conserved genomic locations an...
(PPT), designated for primer binding during the synthesis of positive-stranded DNA (Vargiu et al.2016). Throughout recombination and evolution, many ERVs have undergone genetic erosion, resulting in the absence of sequences within their internal coding domains; in some instances, only the LTR ...