The donated IVM oocytes were in vitro fertilized in G-IVFTMPLUS medium (Vitrolife, 10136) in a humidified atmosphere at 37 °C with 6% CO2in air. Cultured 4-cell, 8-cell embryos, morula and morphological AA grade blastocysts were collected around 48 h, 3 days, 4 days and 5 days ...
Baquedano, E. et al. The Des-Cubierta Cave (Pinilla del Valle, Comunidad de Madrid, Spain): a Neanderthal site with a likely funerary/ritualistic connection. InAbstract Book 6thAnnual Meeting ESHE41 (European Society for the Study of Human Evolution, 2016). Annual Meeting ESHE Alperson-Af...
Because essential genes need to be expressed at a high level, NMD-sensitive mutations in these genes may undergo negative selection. In contrast, the high fraction of NMD-sensitive PTCs in TSGs may indicate positive selection. NMD of TSGs should be favoured in cancer evolution because NMD can l...
Taken together, these data imply that our H3K27ac detection marks previously unannotated human enhancers, which function over considerable evolutionally distance, despite the absence of detectable sequence conservation. This is most likely associated with overall conservation of TF activity between ...
DNA methylation is a fundamental epigenetic mark that governs gene expression and chromatin organization, thus providing a window into cellular identity and developmental processes1. Current datasets typically include only a fraction of methylation sites
Also, we could not retrieve from their notes, relative comorbidities, e.g., diabetes or hypertension. What we wanted to test though was if there is any variability within prostate tissue with time of tissue collection independent of other variables; therefore, knowing associated risk factors may ...
While this region was not fully present on the DGV, it is probable that this gain represents a benign event as other histone clusters have been shown to be preferentially duplicated during evolution60. A 542 kb gain on chromosome 18q23 in KCL037 containing two coding genes, SALL3 and ...
CNAs are important genomic events in the progressive molecular rewiring that takes place during tumor cell evolution2. CNAs can promote tumor progression via alteration of expression levels of genes located at the affected genomic regions3,4,5. Due to transcriptional adaptive mechanisms, however, ...
The development of blood protein profiles in extremely preterm infants follows a stereotypic evolution pattern Wen Zhong Hanna Danielsson Ann Hellström Communications Medicine(2023) Microbial dysbiosis and the host airway epithelial response: insights into HIV-associated COPD using multi’omics profiling ...
Ageing phenotypes, such as years lived in good health (healthspan), total years lived (lifespan), and survival until an exceptional old age (longevity), are of interest to us all but require exceptionally large sample sizes to study genetically. Here we