Also, they have investigated the dynamic activity of signaling pathways along the embryonic body axis, according to the study published this week in the journal Cell. The study has far-reaching clinical implications for understanding the miscarriages and fetal disorders in early embryonic development, ...
During the second week of development, with the embryo implanted in the uterus, cells within the blastocyst start to organize into layers. Some grow to form the extra-embryonic membranes needed to support and protect the growing embryo: the amnion, the yolk sac, the allantois, and the chorion...
Within at most 2 days, the heart has transformed into a single endocardial conduit extending between still paired venous and arterial vessels (Fig.1; see ref.15). The single channel has the embryonic left ventricle as its caudal, and the embryonic right ventricle as its cranial component. Th...
Human cerebral organoids generated from human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) have enormous potential for the study of human brain development and neurological diseases [1,2,3]. For example, three-dimensional organoids have been used as a model to ...
The aim of this study was to determine the main stages of submandibular salivary gland development during the embryonic period in humans. In addition, we studied submandibular salivary gland development in rats on embryonic days 14–16 and expression in the submandibular salivary gland region with th...
R. Characterisation of the human embryonic and foetal epicardium during heart development. Development 142, 3630–3636 (2015). CAS PubMed PubMed Central Google Scholar Krainock, M. et al. Epicardial epithelial-to-mesenchymal transition in heart development and disease. J. Clin. Med. 5, 27 (...
The distribution of the hepatic veins in embryonic and adult human livers. Anterior (A,C) and caudal (B,D–F) views. Panels A–D show the main branches of the hepatic veins in 7 and 10 week-embryos, while panels E,F show the hepatic veins as observed by Fangc.s. (28; reproduced...
This close neurovascular interaction during embryonic brain development that is sealed by space and time is the key missing link in interneuron-based therapy. Interestingly, it has been reported that transplanted neuronal precursors align and migrate along the surface of host blood vessels [37, 38] ...
'Legal sophistry.' That is what Senator Sam Brownback (Republican, KS) calls the newly issued US guidelines governing taxpayer‐funded research with human embryonic stem cells. To tell the truth, Senator Brownback has a point. The guidelines, issued on August 23, specify that researchers with ...
In vitro gametogenesis (IVG) from pluripotent stem (PS) cells provides a framework for clarifying the mechanism of germ cell development9. Accordingly, human PS cells have been induced into hPGCLCs10,11,12, which, after aggregation culture with mouse embryonic testicular or ovarian somatic cells ...