Upon infection, theactivated neutrophils release elastase which then hydrolyzes azurophil granule proteins and extracellular matrixproteins: elastin, collagen, and proteoglycan (4). As a host defense protein, neutrophil elastase degrades bacterial outer membranes and virulence proteins (5, 6). When ...
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recognized as to participate in the clearance of invaded pathogens through its intracellular and extracellular killing as well as antimicrobial activity, and the degradation of extracellular matrix components, including elastin, collagens, fibroncetin and proteoglycans. Assay Characteristics: Sample Type: Se...
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The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has bee...
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