(13, 16). In adults, Dkk-1 is expressed in osteoblasts and osteocytes, and neurons. Cerebral ischemia induces Dkk-1 expression, which contributes to neuronal cell death (17). Dkk-1 also likely has a complex role in cancer, as it has been shown to act as a tumor suppressor and als...
Induction of the Wnt-antagonist, Dickkopf-1 (Dkk1) is involved in tissue repair during inflammation and cellular injury. In this study, we aimed to identify the biological role of Dkk1 in human reflux-esophagitis with respect to cell growth and regulation of Wnt-signaling. Esophageal......
cancer and Alzheimer's disease. The balance between Wnt signaling and DKK-1 inhibition is important for bone homeostasis. Increased expression of DKK-1 are found in lung cancers, esophageal squamous cell carcinomas, and hormone-resistant breast cancers. DKK-1 expression is decreased in malignant me...
Human DKK1 qPCR Primer Pair,即人DKK1 qPCR引物对,主要用于基于SYBR Green的qPCR、One-Step qRT-PCR或semi-quantitative PCR。本引物为预先设计、经过qPCR验证、预混的引物对。 qPCR (Quantitative PCR)即定量PCR,也称实时荧光定量PCR或实时定量PCR (Real-time quantitative PCR)、实时PCR (Real-time PCR),是一种...
dickkopf (Xenopus laevis) homolog 1; dickkopf homolog 1 (Xenopus laevis); dickkopf related protein-1; Dickkopf-1; dickkopf-related protein 1; Dkk1; Dkk-1; hDkk-1; SKdickkopf-1 like Related Research Areas Cancer Biomarkers Negative Regulators of EMT New Tools: for Developmental Research...
This is reflected by the fact that oral cancer is associated with one of the poorest 5-year survival rates of any malignancy in the body. It is becoming increasingly evident that the underlying stroma has an important role to play in tumorogenesis. Our studies focus on the central controller...
Bone marrow stromal cells create a permissive microenvironment for myeloma development: a new stromal role for Wnt inhibitor Dkk1. Cancer Res 2012; 72: 2183–2189. Article CAS PubMed PubMed Central Google Scholar Manier S, Sacco A, Leleu X, Ghobrial IM, Roccaro AM . Bone marrow ...
dickkopf (Xenopus laevis) homolog 1; dickkopf homolog 1 (Xenopus laevis); dickkopf related protein-1; Dickkopf-1; dickkopf-related protein 1; Dkk1; Dkk-1; hDkk-1; SKdickkopf-1 like Related Research Areas Cancer Biomarkers Negative Regulators of EMT ...
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Mast cells are well known for their detrimental impact in allergic disorders, but there is a rising awareness of a role for mast cells in various additional pathologies, including, e.g., fibrosis, atherosclerosis, cancer, obesity and diseases of the skeletal system [4], [5], [6], [7]....