Some Bacteroidetes and other human colonic bacteria can degrade arabinoxylans, common polysaccharides found in dietary fiber. Previous work has identified gene clusters (polysaccharide-utilization loci, PULs) for degradation of simple arabinoxylans. However, the degradation of complex arabinoxylans (containing...
ATRT has no standard treatment, and a major limiting factor in therapeutic development is the lack of reliable ATRT models. We employed CRISPR/Cas9 gene-editing technology to knock out SMARCB1 and TP53 genes in human episomal induced pluripotent stem cells (Epi-iPSCs), followed by brief neural ...
Chromatin Regulation and Genome Maintenance by Mammalian SIRT7 Members of the Sirtuin family of enzymes are important regulators of genomic stability, stress responses, and metabolic programs that impact on human physiology, aging, and age-related disease processes. We previously showed that the mam....
The drug, not related to the sialic acid family, was found to have activity both on the neuraminidase and the haemagglutinin functions of HN. The kinetic analysis we conducted on the hPIV-3 sialidase with suramin (7) showed that the drug did not compete with the substrate. While the ...
This work was supported by CAPES foundation [88881.134342/2016-01], National Council for Science and Technological Development (CNPq) [140.344/2016-0], [311.078/2019-2], [445.766/2015-8]“Multidisciplinary cooperative network to support fisheries management of shrimp stocks in the North and Northeas...
It was not until recent decades, with the development of new techniques, that interest in their nature and their relation with certain diseases awakened1. CA usually increase in number with age in normal human brains, but they are also profuse in selected areas of the brain in several ...
The Chlorovirus genus of the Phycodnaviridae family includes large viruses with a double-stranded DNA genome. Chloroviruses are widely distributed in freshwater bodies around the world and have been isolated from freshwater sources in Europe, Asia, Austr
and Proliferation 1.68 × 10−3–5.20 × 10−8 77 Physiological system development and function 1 Immune Cell Trafficking 1.82 × 10−3–6.81 × 10−12 45 2 Hematological System Development and Function 1.82 × 10−3–5.20 × 10−10 64 3 Tissue Morphology 1.67 × 10−3–2.55 ...
We have focused our research on the possible METCAM/MUC18 expression in normal and cancerous ovarian [8] and its effects on the development of the carcinoma. From the results, as described in the following sections, we believe that METCAM/MUC18 may not be a useful marker for early ...
International Journal of Molecular Sciences Article Mechanistic Analysis of Physicochemical Cues in Promoting Human Pluripotent Stem Cell Self-Renewal and Metabolism Nan Hai †, Dong Woo Shin †, Huanjing Bi †, Kaiming Ye and Sha Jin * Department of Biomedical Engineering, Thomas J. Watson ...