The COVID-19 pandemic is an ongoing global health threat, yet our understanding of the dynamics of early cellular responses to this disease remains limited1. Here in our SARS-CoV-2 human challenge study, we used single-cell multi-omics profiling of nasop
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4a,b). A fraction of the glandular epithelial cells express molecules characteristic of uterine milk in the secretory stage (PAEP, CXCL8). Fig. 2: Temporal and spatial dynamics of endometrial epithelial cells. a, Schematic illustration of epithelial subsets in the differentiated endometrium ...
Chromatin modifiers also target inflammation and oxidative stress in vascular endothelial injury. Recent research has shown that DOT1L changes the genomic accessibility of NF-kB, regulates the expression of the downstream inflammatory factors CCL5 and CXCL10 of the NF-kB pathway, and prevents the occ...
ELISA Kits ELISA Kits Growth factors and hormones ELISA kits FunctionChemotactic for monocytes and T-lymphocytes. Binds to CXCR3. Sequence similaritiesBelongs to the intercrine alpha (chemokine CxC) family. Post-translationalmodificationsCXCL10(1-73) is produced by proteolytic cleavage after secretion ...
CXCL1 P09341 Growth-regulated alpha protein + − 11301 7436 1.3E+07 1 CXCL12 P48061 Stromal cell-derived factor 1 + − 10666 7610 1.4E+09 3 CXCL3 P19876 C-X-C motif chemokine 3 + − 11342 7509 1.1E+09 6 CXCL5 P42830 C-X-C motif chemokine 5 + − 11972 7706 3.5E+08 ...
Supplementary Fig.1B). The IFN-I response gene set included chemokines (CXCL9/10/11), MHC class I (MHC-I) molecules (HLA-A/B/C/E/Fandβ2m), proteasome subunits (PSMA2andPSMB9), IFN regulatory factors (IRF1/2/8), and IFN-induced molecules (ISG20, IFI35, andSTAT1) (Fig.1B; ...
To determine whether repeated injury alters the ability of IECs to respond to inflammatory stimuli, we measured secretion of CXCL8 (IL-8), one of the most abundantchemokinessecreted from IECs (Allaire et al., 2021;Noel et al., 2017;Rees et al., 2020a,2020b). The amount of IL-8 produ...
6i). Notably, senescence markers (CDKN1A, CDKN2A and CDKN2B) and SASPs (IL-6, TNF and CXCL8) were elevated in the si-FOXP1 groups, whereas cell cycle-related genes (CCNA1, CCNB1 and CCND1) decreased (Fig. 6j). Si-FOXP1 also increased expression in pathways linked to cellular ...
Strikingly, while DT-061 treatment resulted in SA-BGal+ cell reduction, OA treatment induced a significant increase in cellular senescence (SA-BGal, CDKN1A) and SASP markers (IL6 and CXCL1) (Fig. 3g–k). Strengthening the notion that PP2A is central for the Pep 14 mechanism of action, ...