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Human neurons in autaptic culture. (A) Schematic diagram of the autaptic culture protocol for hiNs. IPSCs were plated and infected with Ngn2, rtTA and eGFP on day −1, followed by application of doxycycline to start Ngn2 expression and puromycin selection on day 0 to 3. HiNs were co-cu...
Single-cell transcriptomic analyses of human and mouse cortex show an increased diversity of glutamatergic neuron types in supragranular cortex in human and pronounced gradients as a function of cortical depth. To probe the functional and anatomical correlates of this transcriptomic diversity, we ...
Surprisingly, we found that FGF13 is highly expressed in a subset of human cortical neurons through to adulthood, in particular in several IN subtypes, including ID2, LAMP5-NOS1, PV-SCUBE3, and PV (Figure 3B). To validate this protracted FGF13 expression, we focused on NDNF+ ID2s, ...
neurons in the retina—that run through it. It is also identified as Brodmannarea 17. It is at this level that the impulses from the separate eyes meet at common cortical neurons, so that when the discharges in single cortical neurons are recorded it is usual to find that they respond to...
Thus CTX0E16 neurons can be used to study cortical cell function, and furthermore, as these neurons express a range of disease-associated genes, they represent an ideal platform with which to investigate neurodevelopmental mechanisms in native human cells in health and disease....
microfluidic device, a 3D3C chip, was used to coculture human induced pluripotent stem cell (hiPSC)-derived neurons and CMs. The 3D3C chip enabled the coculture of both cell types with their respective culture media in their own compartments while allowing the neuronal axons to traverse between...
The generation of new neurons in the adult brain is a currently accepted phenomenon. Over the past few decades, the subventricular zone and the hippocampal dentate gyrus have been described as the two main neurogenic niches. Neurogenic niches generate new neurons through an asymmetric division process...
Intraneuronal Aβ42 immunoreactivity in a representative normal 3-month-old brain (Figure 1c, left) was of markedly less intensity than that in the brain of a 3-year-old with DS (Figure 1c, center) or the brain of a nondemented 76-year-old (Figure 1c, right). Thus neurons from ...
Rotating reconstruction of neurons. Credit: Charité | Sabine Grosser To be able to observe the flows of signals between neighboring neurons in the outermost layer of the human neocortex, the team developed an improved version of what is known as the “multipatch” technique. This allowed the re...