In modern biology, the correct identification of cell types is required for the developmental study of tissues and organs and the production of functional cells for cell therapies and disease modeling. For decades, cell types have been defined on the basis of morphological and physiological markers ...
The development of single-cell and spatial transcriptomics methods was instrumental in the conception of the Human Cell Atlas initiative, which aims to generate an integrated map of all cells across the human body. These technology advances are bringing
and obtained more than 100,000 cells, each with about 2,000 genes. Through calculation and analysis, the team took the lead in creating a fine single cell map of human limb development including all cell types.
Monitor the distribution of company property, such as laptop computers and cell phones, to employeesIf you are using U.S. Payroll, you can enter and maintain your employee information in Human Resources and those transactions automatically will update your payroll records.In...
Eight cell clusters expressing known markers of the major cell types in the epidermis were identified (Figure S1C). These included four minor populations: T cells, innate lymphoid cells, DCs, and keratinocytes. The one major LC population (Figure S1D) was sub-clustered into four discrete LC ...
Since the first report of these cells in 2006, human iPSCs have been derived from many cell types, including blood cells [29,30,31,32]. The original protocol, which involved the integration of transcription factor combinations into the cell genome, has been refined and now makes use of ...
Most immune cell types were increased in polyps compared to normal tissues, including CD4+ T cells, although many were not different between polyp subtypes (Figure 6C; Figure S6D; Tables S3 and S4). Strikingly, CD8+ T cells, natural killer (NK) cells, and γδT cells (labeled cytotoxic ...
early schistosomula, using the same dissociation and cell staining protocol16, we were, however, not able to capture all cell types known to be present in this developmental stage, such as flame cells of the protonephridia system35. Limitations have been previously reported for the FDA/PI ...
(Fig.1g). Overall, most clusters were distinct; however, one cluster appeared to bridge between multiple other cell types and expressed an ambiguous range of developmental markers. This cluster was composed mostly of fetal cells, which suggests that these were largely unspecified immature cells (...
A small cell cluster with high expression of limbal progenitor cell (LPC) markers was identified and shown via pseudotime analysis to give rise to five other cell types representing all the subtypes of differentiated limbal and corneal epithelial cells. A novel putative LPCs surface marker, GPHA2...