a, A phylogenetic tree for all species from the class Clostridia in the VMGC. The tree branches are coloured to represent different orders. The numbers on the branches represent bootstrap values, and the size of the point on the tip of each branch is positively correlated with the number of...
In addition to GEF proteins, yeast has been useful to deepen the understanding of the other class of RAS regulators, GTPase activating proteins (GAPs), IRA in yeast. Indeed, the functions of GAP-coding NF1 gene, whose mutations are responsible for neurofibromatosis type 1, were clarified ...
As a serine/threonine protein kinase, mTOR is one of the key regulators of the class I PI3K pathway, and it has a negative effect on the formation of autophagy [45,46]. Class I PI3K is a traditional upstream activator of mTOR. A previous study reported that ZIKV NS4A and NS4B ...