Genes for the whole-body map of gene co-expression were selected on the basis of variance and expression. A log2 expression cut-off of 1 TPM on average for each gene and variance of at least 1 were used to ensure enough information for co-expression analyses. Gene co-expression values we...
We used permutation multivariate analysis of variance (PERMANOVA) based on the Bray–Curtis distance matrix to estimate the variance explained by age, sex (self-report), body mass index (BMI), smoking, tumor location and stage in the Guangzhou cohort. We also used PERMANOVA to evaluate the ...
Here, I review how single and multiple human organ chip systems have been used to model complex diseases and rare genetic disorders, to study host–microbiome interactions, to recapitulate whole-body inter-organ physiology and to reproduce human clinical responses to drugs, radiation, toxins and ...
Body composition QTLs identified in intercross populations are reproducible in consomic mouse strains. PLOS ONE 10, e0141494 (2015). PubMed PubMed Central Google Scholar Leek, J. T. & Peng, R. D. Reproducible research can still be wrong: adopting a prevention approach. Proc. Natl Acad. ...
The measured pH of the luminal contents for device types 1 through 4 was consistent with the expected pH gradient across the intestinal tract4,5, covering the duodenum, jejunum, ileum and ascending colon (Fig.1a). The pH in type 1 and 2 devices was significantly different from type 3 and...
Named entities that directly denote human body parts are considered explicit anatomical related entities (e.g., colon). Name entities that do not refer to but are highly related to human body parts are defined as implicit anatomical related entities (e.g., colonoscopy). In our previous ...
Triple-jet IAMF enables high-throughput fabrication of monodisperse, hollow, thin-shelled microcapsules for controlled spheroid, embryoid body, and cardiosphere formation In-air microfluidics (IAMF) is a recently invented jet-based microfluidic technology that enables ultra-high-throughput, oil-free, chi...
In this work, the AhR activation caused by the metabolic output of the gut fermentation process in a short-term (72 h) and static in vitro simulation of the human colon was studied. Ultimately, we hope this analysis will provide valuable insights to motivate the study of complex mixtures of...
Although previously it was thought the human colon did little more than resorb water, there is a new focus on the significance of colon for human health, including immune responsivity43, nutrient absorption, and energy regulation44. Internal fermentation increases the body’s capacity to absorb ...
Imaging-based proteomics has a clear advantage, namely analysing proteins in their native location at single-cell resolution. To this end, the HPA has developed industrial scale epitope-directed Abs for community use.HPA also integrates multi-omics data. It contains extensive transcriptome data and ...