The concept of variance explained is not always relevant to individual-level risk prediction or drug development, whereas the genetic architecture of a given trait or disease can be more pertinent. Genetic architecture is variable in time and place and can be theoretically influenced by phenotypic me...
We used the R package ‘PCAtools’ v2.12.0 to determine the count of PCA components that cumulatively explained 90% of the variance in the data for each block. This number varied from 243 to 349 across the blocks. However, the blocks also shared a subset of perturbation conditions, and ...
with conserved mean expression explained more heritability or enriched more GWAS signals of complex traits than diverged ones (one-side Student’sttest,p< 2.20×10−16), and this was consistent across tissues and traits in both humans and cattle (Figs.6and7, Additional files8,9and10: Table ...
This might be explained by quiescent adult epicardial cells being less responsive to EMT-driving stimuli as previously demonstrated in cultured adult EPDCs48. Current knowledge suggests that epicardial cells undergo EMT, forming EPDCs, which subsequently differentiate into other cardiac cell types3,4, ...
This lack of consensus can be explained by the intrinsic variability and complexity of both FBS and hPL: both their composition is not completely defined in terms of protein, cytokine and elementary components and, moreover, hPL manufacturing is not a standardized process. All these factors increas...
8). In PERMANOVA, age explained a small and non-significant amount of overall variance of the microbial pathway variation (R2 = 0.005, P = 0.13). To identify specific microbial pathway associated with age, we tested the associations between age and abundances of metaCyc30 pathways (...
(DCs) as well as other myeloid lineages and NK cells, decreases the functionality of the engrafted HIS. The small frequencies of these cell populations can be explained, in part, by the limited biological cross-reactivity of the non-redundant cytokines that promote lineage differentiation21. ...
Major variables explained above (i.e. measured substance, age group, country, and sampling year) created a high data categorization. For this reason, other variables which were considered comparatively less important for our analysis, for example the gender, area (urban, suburban), or the sample...
accumulation in human cells [15]. The human deficiency of Neu5Gc is explained by an inactivating mutation in the gene encoding CMP-N-acetylneuraminic acid hydroxylase (CMAH), the rate-limiting enzyme in generating Neu5Gc in cells of other mammals [16]. This deficiency also results in an ...
1C). Thus, an overall low expression of LDHA in islets can be explained by the lower percentage of α-cells present in islets, compared to β-cells and the strong repression of LDHA within β-cells. Download: Download high-res image (1MB) Download: Download full-size image Fig. 1. ...